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A B S T R A C T
Epidermal proliferation and differentiation is a physiological process which plays
crucial role in protecting human body from external environment. Ichthyosis
vulgaris is a disease caused by disruption of epidermal differentiation process.
Disrupted of profilaggrin conversion to filaggrin caused by mutations from the
filaggrin gene (FLG) located on chromosome 1q21. Recently, caused of ichthyosis
vulgaris is mutation of the CASP14 gene on chromosome 19p13.12 which produces
caspase-14, is involved in the proteolytic degradation of filaggrin. Clinical
manifestations of ichthyosis vulgaris are hyperlinear palmar and plantar, keratosis
pilaris, xerosis, and localized or generalized scaling of the skin. Application of
emollients, humectants and keratolytic agents are the main treatment of ichthyosis
vulgaris. Further research on caspase-14 as a therapeutic target is needed in the
treatment of ichthyosis vulgaris.