The Role of NT-proBNP in the Diagnosis of Peripartum Cardiomyopathy with Multiple Left Ventricular Thrombus: A Case Report
DOI:
https://doi.org/10.37275/bsm.v8i10.1090Keywords:
Biomarkers, Heart failure, Left ventricular thrombus, NT-proBNP, Peripartum cardiomyopathyAbstract
Background: Peripartum cardiomyopathy (PPCM) is a rare but serious condition characterized by left ventricular dysfunction in late pregnancy or early postpartum. Early diagnosis is essential to prevent complications such as thromboembolism. N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a promising biomarker for the diagnosis of PPCM.
Case presentation: An 18-year-old female presented with progressive shortness of breath and generalized edema. Physical examination and echocardiography revealed acute heart failure with multiple left ventricular thrombus. Very high levels of NT-proBNP (1,796 pg/mL) supported the diagnosis of PPCM. The patient was successfully treated with standard heart failure therapy and anticoagulants.
Conclusion: This case report highlights the importance of NT-proBNP in the early diagnosis of PPCM and detecting of thromboembolic complications. Significant increases in NT-proBNP levels, even without obvious symptoms, should be promptly evaluated for PPCM, especially in high-risk populations.
Authors
- Yashinta Octavian Gita Setyanda1
- Rismawati Yaswir2*
- 1Clinical Pathology Resident, Department of Clinical Pathology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
- 2Staff, Department of Clinical Pathology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Corresponding author Rismawati Yaswir — rismawatiyaswir@med.unand.ac.id
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