The Significance of TGF-β Expression in Predicting Lymphovascular Invasion and Lymph Node Metastasis in Colorectal Cancer
DOI:
https://doi.org/10.37275/bsm.v9i1.1182Keywords:
Colorectal cancer, Immunohistochemistry, Lymph node metastasis, Lymphovascular invasion, TGF-βAbstract
Background: Colorectal cancer (CRC) is a major health burden globally. The prognosis of CRC is strongly influenced by the presence of lymphovascular invasion (LVI) and lymph node (LN) metastasis. Transforming growth factor-beta (TGF-β) is a cytokine with a complex role in CRC progression. This study aimed to evaluate the significance of TGF-β expression in predicting LVI and LN metastasis in CRC.
Methods: This cross-sectional study involved 50 patients diagnosed with CRC. The expression of TGF-β was assessed using immunohistochemical staining and the Allred scoring system. The relationship between TGF-β expression and the presence of LVI and LN metastasis was analyzed using the Chi-square test.
Results: High TGF-β expression was significantly associated with both LVI (p = 0.011) and LN metastasis (p = 0.012) in CRC. Patients with high TGF-β expression had a higher risk of LVI and LN metastasis compared to those with low TGF-β expression.
Conclusion: TGF-β expression is a significant predictor of LVI and LN metastasis in CRC. This finding has potential implications for risk stratification and treatment decisions in CRC patients.
Authors
- Julpa Nurul Aini1*
- Aswiyanti Asri1
- Noza Hilbertina1
- Tofrizal1
- Avit Suchitra2
- Husna Yetti3
- 1Department of Anatomical Pathology, Faculty of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
- 2Department of Surgery, Faculty of Medicine, Universitas Andalas/Dr. M. Djamil General Hospital, Padang, Indonesia
- 3Department of Public Health Sciences, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Corresponding author Julpa Nurul Aini — julpanurulaini1987@gmail.com
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