The Effect of High-Intensity Interval Training on Interleukin-6 Levels in Hypertensive Individuals: A Systematic Review and Meta-Analysis
DOI:
https://doi.org/10.37275/bsm.v9i6.1296Keywords:
High-intensity interval training, HIIT, Hypertension, Interleukin-6, IL-6Abstract
Background: High-intensity interval training (HIIT) has emerged as a time-efficient exercise modality with potential benefits for hypertensive individuals. Interleukin-6 (IL-6), a cytokine with both pro- and anti-inflammatory properties, has been implicated in the development and progression of hypertension. This meta-analysis aimed to investigate the effect of HIIT on IL-6 levels in hypertensive individuals.
Methods: A systematic search of electronic databases (PubMed, Scopus, Web of Science) was conducted to identify relevant studies published between 2013 and 2024. Studies were included if they met the following criteria: (1) randomized controlled trials; (2) included hypertensive participants; (3) compared HIIT to a control group (no exercise or moderate-intensity continuous training); (4) measured circulating IL-6 levels; and (5) provided sufficient data for meta-analysis. Data were extracted and pooled using a random-effects model.
Results: Seven studies met the inclusion criteria, comprising a total of 328 participants. The meta-analysis revealed a significant decrease in IL-6 levels following HIIT compared to the control group (standardized mean difference [SMD] = -1.27, 95% confidence interval [CI] = (-1.81 to -0.73, p = 0.002). Subgroup analysis showed that HIIT interventions lasting ≥ 8 weeks were associated with a greater reduction in IL-6 levels compared to shorter interventions.
Conclusion: HIIT appears to be an effective exercise modality for reducing IL-6 levels in hypertensive individuals. This finding suggests that HIIT may have anti-inflammatory effects and could be a valuable non-pharmacological strategy for managing hypertension.
Authors
- Ainnaya Natin Ristanti1*
- Roman Ardian Goenarjo2
- 1Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
- 2Department of Medical Physiology and Biophysics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia/Center for Sport and Exercise Studies (SES), IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia
Corresponding author Ainnaya Natin Ristanti — ainnayanatin303@gmail.com
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