Case Series of Rare Head and Neck Plasmacytoma: Experiences in Indonesia
DOI:
https://doi.org/10.37275/bsm.v7i9.867Keywords:
Multiple myeloma, Neoplasm, Plasma cell granuloma, PlasmacytomaAbstract
Background: Solitary plasmacytoma (SP) is a rare case of plasma cell neoplasms, which only represent 5-10% of all plasma cell neoplasms that afflict two or three people per every 100,000 of the general population. This neoplasm is divided into solitary plasmacytoma of the bone (SBP) and solitary extramedullary plasmacytoma (SEP), depending on the location. Due to the rarity, SBP can be misdiagnosed as multiple myeloma (MM) while SEP as plasma cell granuloma, whereas the treatments are very different. This study aimed to present our experiences in diagnosing SP in the head and neck to differentiate them from MM and plasma cell granuloma.
Case presentation: One case of multiple solitary plasmacytomas of the bone (SPB) in the frontal bone and one case of intraoral solitary extramedullary plasmacytoma (SEP) were presented. The SBP showed abnormality in the laboratory and the CT showed a punch-out lesion which is similar to MM. The SEP showed normal laboratory findings, but the histopathology mimicked plasma cell granuloma. Both immunohistochemistry was positive for CD138, and the SEP diagnosis was confirmed by Ki67 and κ-light chain. Complete examination from history taking, physical examination, radiology and laboratory findings, bone marrow morphology, and histopathology including immunohistochemistry examination, are very important to determine the correct diagnosis.
Conclusion: the case was diagnosed as head and neck solitary plasmacytoma.
Authors
- Maya Sofa1*
- Maman Abdurahman1
- Kiki A. Rizky1
- Yohana Azhar1
- Bethy Hernowo2
- Adji Kusumadjati3
- Monty P. Soemitro1
- 1Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
- 2Department of Anatomical Pathology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
- 3Department of Radiation Oncology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, Indonesia
Corresponding author Maya Sofa — mayasf11.surg@gmail.com
Article history
- Submitted
- Accepted
- Published
Downloads
Published
Issue
Section
License
As our aim is to disseminate original research article, hence the publishing right is a necessary one. The publishing right is needed in order to reach the agreement between the author and publisher. As the journal is fully open access, the authors will sign an exclusive license agreement.
The authors have the right to:
- Share their article in the same ways permitted to third parties under the relevant user license.
- Retain copyright, patent, trademark and other intellectual property rights including research data.
- Proper attribution and credit for the published work.
For the open access article, the publisher is granted to the following right.
- The non-exclusive right to publish the article and grant right to others.
- For the published article, the publisher applied for the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
