The Jarisch-Herxheimer Reaction on Secondary Syphilis Patient with Roseola Syphilitica and Human Immunodeficiency Virus Co-Infection: A Case Report

Authors

  • Ni Made Dwi Puspawati Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Indonesia
  • I Gusti Ayu Agung Elis Indira Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Indonesia
  • Adelia Suryani Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Indonesia
  • Putu Setiani Department of Neurology, Kasih Ibu Hospital Kedonganan, Denpasar, Indonesia

DOI:

https://doi.org/10.37275/bsm.v8i3.939

Keywords:

Jarisch-Herxheimer reaction, Roseola syphilitica, Sexual transmitted disease, Syphilis

Abstract

Background: The Jarisch-Herxheimer reaction is an inflammatory reaction that occurs within 12 hours after administration of antibiotic therapy for spirochaeta species like Treponema pallidum. The reaction includes fever, headache, reappearing or worsening of skin lesions, lymphadenopathy, pharyngitis, malaise, and myalgias.

Case presentation: We present a 27-year-old man complaining of high fever 4 hours after the injection of benzathine penicillin. The patient also complained of headaches, body aches and aches. There were no complaints of shortness of breath, itching, skin blisters, red eyes, or sores on the genitals. History of take any medication was denial by the patient. After treatment by giving antipyretics and corticosteroids and getting enough rest, in the 24 hours, the patient was improved.

Conclusion: The Jarisch-Herxheimer reaction is an inflammatory reaction that occurs after the administration of antibiotic therapy for spirochaeta species like Treponema pallidum.

Authors

  • Ni Made Dwi Puspawati1*
  • I Gusti Ayu Agung Elis Indira1
  • Adelia Suryani1
  • Putu Setiani2
  1. 1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana/Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Indonesia
  2. 2Department of Neurology, Kasih Ibu Hospital Kedonganan, Denpasar, Indonesia

Corresponding author Ni Made Dwi Puspawati — dwi.puspawati@yahoo.com

Article history

  1. Submitted
  2. Accepted
  3. Published

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Published

2023-12-19

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How to Cite

1.
Dwi Puspawati NM, I Gusti Ayu Agung Elis Indira, Adelia Suryani, Putu Setiani. The Jarisch-Herxheimer Reaction on Secondary Syphilis Patient with Roseola Syphilitica and Human Immunodeficiency Virus Co-Infection: A Case Report. Bioscmed [Internet]. 2023 Dec. 19 [cited 2026 Aug. 6];8(3):4117-22. Available from: https://bioscmed.com/index.php/bsm/article/view/939

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