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Abstract

A B S T R A C T
Introduction Systemic Lupus Erythematosus (LES) is a chronic
autoimmune inflammatory disease affecting many organ systems with varied
clinical manifestations, disease course and prognosis. One of the clinical
manifestations that can occur is depression as much as 25%. In LES
patients, there is an increase in proinflammatory cytokines, one of which is
IL-6, which is often associated with contributing to the pathophysiology of
depression. The purpose of this study was to determine the relationshi p
between serum IL-6 levels and the degree of depression in LES patients at
RSUP DR. Mohammad Hoesin Palembang. Methods, analytic observational
study in the form of correlation test with cross sectional design which was
conducted in the Internal Medicine room RSUP DR. Mohammad Hoesin
Palembang from May 2019 to March 2020. The number of study subjects
was 40 samples who were LES patients with depression who had been
calculated using the BDI (Beck's Depression Inventory). All subjects were
examined for serum IL-6 levels and evaluated for factors that influence it.
Results, there were 40 study subjects aged 18-56 years. The median degree
of depression was 16 with a range of values from 10 to 40. There were 17
people (42.5%) with mild depression degree, 14 people (35%) moderate
depression, and 9 people (22.5%) major depression. In LES activities, there
were 5 people (12.5%) with light LES activities, 20 people (50%) with
moderate LES activities, and 15 people (37.5%) with heavy LES activities.
The mean serum IL-6 level was 11.57 pg / mL with a value range of 1.1-50pg
/ mL. There was a significant correlation between the degree of depressi on
and LES activity (p = 0.004; r = 0.444) and between serum IL-6 levels and
the degree of depression (p = 0.025; r = 0.169). However, there was no
significant correlation between serum IL-6 levels and LES activity (p = 0.057;
r = 0.304). Conclusion, there is a relationship between serum IL-6 levels and
the degree of depression in LES patients at Dr. Moh. Hoesin Palembang with
a very weak correlation.

Keywords

IL-6 Systemic Lupus Erythematosus (LES) Depression

Article Details

How to Cite
Suharno, S., Eddy Mart Salim, Ali Apriansyah, Taufik Indrajaya, Zen Ahmad, & Erial Bahar. (2021). Relationship between Interleukin 6 Serum Levels and Degree of Depression in Systemic Lupus Erythematosus Patients Internal Disease in Dr. Moh Hoesin Palembang. Bioscientia Medicina : Journal of Biomedicine and Translational Research, 5(2), 320-331. https://doi.org/10.32539/bsm.v5i2.224