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A B S T R A C T
Renal pruritus (RP) is a condition or symptom that is often found in end-stage
chronic kidney disease (CKD) undergoing hemodialysis (HD). The etiology of RP is
multifactorial, one of it due to inflammation mediated by interleukin 2 (IL-2). Study
on the correlation between serum level of IL-2 and the severity of RP is still limited.
This study will analyze the correlation between serum level of IL-2 in patients
undergoing HD and the severity of RP. Our method is cross sectional design at
Hemodialysis Installation of Dr. Mohammad Hoesin Hospital. Serum level of IL-2
examined by ELISA, the severity of RP assessed by a 5 dimensional pruritus scale.
Inclusion criteria in this study included HD patients with RP ≥ 9, age ≥ 18 years and
willing to sign informed consent. The results from 28 male (59.6%) and 19 female
(40.4%) are the mean serum level of IL-2 (pg/ml) is 0.424 ± 0.077. The mean RP
severity score is 18.98 ± 2.74. A strong positive correlation between serum level of
IL-2 and the severity of RP (r = 0.750, p = 0,000). Our conclusion is the increase of
serum level IL-2 in line with severity of RP.