Effectiveness of Renal Denervation Therapy in Persistent Hypertension: A Meta-Analysis
DOI:
https://doi.org/10.37275/bsm.v8i8.1049Keywords:
Meta-analysis, Persistent hypertension, Renal denervation therapyAbstract
Background: Persistent hypertension is a global health problem that requires effective therapy. Renal denervation (RDN) therapy is emerging as a promising new option. This meta-analysis aims to evaluate the effectiveness of RDN in patients with persistent hypertension.
Methods: We performed a systematic search in PubMed, Scopus, and the Cochrane Library for studies evaluating the effectiveness of RDN in patients with persistent hypertension. Data were extracted and analyzed using a random effects model.
Results: A total of 12 studies with a total of 1,024 patients were included in this meta-analysis. RDN demonstrated significant reductions in systolic and diastolic blood pressure compared with controls (MD -12.3 mmHg [95% CI -15.8 to -8.8] for systolic blood pressure and MD -6.1 mmHg [95% CI -8.2 to -4.0] for blood pressure diastolic). The effectiveness of RDN is higher in patients with more severe hypertension and in patients who are unresponsive to antihypertensive drugs.
Conclusion: RDN is an effective therapy for persistent hypertension, especially in patients with more severe hypertension and in patients who are unresponsive to antihypertensive drugs.
Authors
- Deddy Primadona Mulia1*
- Syahpri Putra Wangsa1
- Kgs. M. Yusuf Arief Akbar1
- Edy Nur Rachman1
- Chairil Makky1
- Eva Julita1
- Zulkhair Ali2
- Novadian Suhaimi2
- Suprapti Slamet2
- Ian Effendi2
- 1Fellow of Kidney and Hypertension Division, Department of Internal Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
- 2Clinical Educator Lecturer, Kidney and Hypertension Division, Department of Internal Medicine, Universitas Sriwijaya/Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
Corresponding author Deddy Primadona Mulia — dprimadona@gmail.com
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