Accreditation
SINTA 2Nationally Accredited Journal
Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Articles
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Relationship between Serum p-Tau Levels and Impaired Cognitive Function in Type 2 Diabetes Mellitus
Views: 590Downloads: 359Background: Type 2 diabetes mellitus (Type 2 DM) is a metabolic disease that causes a global crisis that threatens health and the world economy. Impaired cognitive function is a key factor in reducing health-related quality of life in type 2 DM patients. Phosphorylated Tau (p-Tau) is a microtubule protein that functions in cell signaling, synaptic plasticity, and regulation of genome stability. A malfunction of p-Tau will cause disruption of cell signaling, which can result in impaired cognitive function. This study aims to assess the relationship between serum p-Tau levels and impaired cognitive function in type 2 diabetes mellitus patients.
Methods: This research is an observational study, comparative analysis with a cross-sectional design with a sample of 60 type 2 diabetes mellitus patients who sought treatment at the endocrine polyclinic at Dr. M. Djamil General Hospital Padang. Cognitive function was assessed using MoCa-Ina. Serum p-Tau levels were measured using the ELISA method. Data analysis was carried out using SPSS.
Results: The average serum p-Tau level in type 2 diabetes mellitus patients with impaired cognitive function was 542.9 pg/ml. The cut-off point for serum p-Tau levels which is associated with impaired cognitive function in type 2 diabetes mellitus patients is 517.2 pg/ml. There was a significant relationship between serum p-Tau levels and impaired cognitive function in type 2 diabetes mellitus patients (p=0.039).
Conclusion: There is a significant relationship between serum p-Tau levels and impaired cognitive function in type 2 diabetes mellitus patients.
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Senescence-Induced Atherosclerosis: The Potency of Senolytic Therapy
Views: 685Downloads: 544The aging process is an inevitable occurrence that involves physiological changes at the cellular level. The presence of intrinsic and extrinsic stressors can cause cellular damage, leading to senescence and premature aging. Senescent cells undergo activation of the p53/p21 and p16INK4a pathways, induce cell cycle arrest, increased expression of senescence-associated beta-galactosidase (SA-β-Gal), and secretion of SASP (senescence-associated secretory phenotype), leading to "inflamm-aging" or chronic inflammation associated with senescence. These premature aging and “inflamm-aging” accelerates the occurrence of age-related diseases, one of which is atherosclerosis. The relationship between premature aging, senescence, and atherosclerosis has been a focus of research on pathogenesis, prevention, and therapy. Recent research has emphasized the crucial role of senolytics, compounds or agents capable of eliminating senescent cells, in inhibiting the progression of atherosclerosis and slowing down premature aging. Obtaining a more comprehensive understanding of the processes and effectiveness of senolytics in premature aging and atherosclerosis should facilitate the development of more potent medicines to mitigate side effects in the management of cardiovascular disease and extend longevity.
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Elizabethkingia meningoseptica Carbapenem Resistance in Cerebrospinal Fluid Cultures of Patients Suspected of Bacterial Meningitis: A Case Report
Views: 577Downloads: 510Background: Elizabethkingia meningoseptica is a Gram-negative bacterium that rarely causes meningitis in children. These infections are often resistant to carbapenem antibiotics, making diagnosis and treatment more complicated.
Case presentation: A 1-month-old male patient was treated to the PICU of Dr. M. Djamil General Hospital Padang with symptoms of decreased consciousness, seizures, and fever. The patient was diagnosed with bacterial meningitis and was referred from Sungai Dareh Regional General Hospital with previous therapy for 4 days. A cerebrospinal fluid examination showed increased protein and decreased glucose, and a CT scan showed hydrocephalus. The cerebrospinal fluid culture showed growth of Elizabethkingia meningoseptica which was resistant to imipenem and meropenem. The patient was treated with a combination of non-carbapenem antibiotics and recovered from meningitis.
Conclusion: Carbapenem-resistant Elizabethkingia meningoseptica is a rare causative agent of meningitis in children. Early diagnosis and treatment with appropriate non-carbapenem antibiotics are essential to increase the chance of cure.
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Rheumatic Heart Disease in East of Bali Indonesia
Views: 603Downloads: 450Background: Rheumatic heart disease remains to be the most acquired heart disease among people aged <25 years. Despite improvements in high sociodemographic countries, low and low-middle sociodemographic countries have been less successful in lowering the burden of RHD.1 However, data of patient with RHD is still lacking in Indonesia, especially in Bali. Karangasem is a rural area, one of the regencies in the eastern part of Bali.
Methods: This retrospective study was performed between January 2023 and January 2024 at two hospitals in Karangasem Regency, Karangasem Regional General Hospital and BaliMed Karangasem Hospital. These two hospitals were the only hospital in Karangasem regency. The study population comprised all patients who were diagnosed with RHD. Patient characteristics and echocardiographic parameters were collected retrospectively from medical records.
Results: Data from 101 patients with RHD were collected. They were predominantly female (73.3%) young adults (mean ages 41.97 years), graduated from primary school (58.4%), unemployed (26.7%), and mostly from the Karangasem subdistrict (34.7%). Mitral stenosis and mitral regurgitation were the same counts (65.3%), with mixed valve lesions (mitral and aortic) as the most common lesion (45.5%). Fifty-eight patients (57.4%) had secondary tricuspid regurgitation, with 6 patients with TR V-Max >3.4m/s. Atrial fibrillation was a common complication (47.5%). Most patient with RHD had preserved Left Ventricular Ejection Fraction (LVEF >50%). Only a quarter of patients had reduced RV contractility (TAPSE <17mm). All of the patients with AF were given warfarin. All under 40-year-old patients were given a benzathine penicillin G injection. Only 7 patients had a history of valve surgery.
Conclusion: Mixed valve lesion (mitral and aortic) was the most observed condition of valve lesion in RHD with the same count of mitral stenosis and mitral regurgitation. Characteristic of patients in this study were predominantly female, young adult, graduated from primary school, unemployed, had preserved LV function, normal RV contractility, high prevalence of AF with all prescribed warfarin, all of under 40 years were given antibiotics prophylaxis.
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Anesthetic Management of a Single Ventricle in Pediatric Patient Undergoing Open Duodeno–Duodenostomy Surgery: A Case Report
Views: 479Downloads: 387Background: Duodenal atresia is a rare congenital disorder characterized by blockage of the small intestine. Open duodeno-duodenostomy is the surgery of choice to correct this condition.
Case presentation: We report the case of a three-day-old baby girl with duodenal atresia and a functional single ventricle who underwent open duodeno-duodenostomy. The patient was born via caesarean section due to indications for a previous caesarean section in the mother and congenital abnormalities in the fetus. At birth, the patient showed signs of intestinal obstruction and cyanosis. Preoperative physical and laboratory examinations confirmed duodenal atresia and cardiac abnormalities. The patient underwent an open duodeno-duodenostomy without complications. The patent ductus arteriosus must be kept open to maintain systemic perfusion by maintaining PaO2 at 40 to 45 mmHg and SaO2 at 70% to 80%, along with the administration of prostaglandin agents. Good perioperative management and improvements in surgical procedures will increase the life expectancy of patients with single ventricle problems, especially hypoplastic left heart syndrome. The use of low-dose fentanyl induction agent, 1 MAC sevoflurane, and atracurium has been proven to produce favorable outcomes in these patients.
Conclusion: Open duodeno-duodenostomy is a safe and effective operation for duodenal atresia. The patient in this case recovered well after surgery. Open duodeno-duodenostomy should be considered as the primary treatment option for duodenal atresia.
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Combination Therapy of Topical Antioxidant Gel and Platelet-Rich Plasma (PRP) in Pyoderma Gangrenosum Ulcer: A Case Report
Views: 682Downloads: 426Background: Pyoderma gangrenosum (PG) is a rare necrotic ulcerative skin disease, often associated with an underlying systemic condition. Bacterial coinfection in PG can worsen the course of the disease and slow healing.
Case presentation: We report the case of a 25-year-old woman with PG of her left leg complicated by Pseudomonas aeruginosa co-infection. The patient had a history of poorly treated psoriasis. The diagnosis is made based on disease history, physical examination, microbiological examination, and histopathological examination. The patient was treated with oral levofloxacin and topical combination therapy of astaxanthin and platelet-rich plasma (PRP) with wound debridement. Significant clinical improvement was achieved within six weeks.
Conclusion: PG with bacterial coinfection requires appropriate diagnosis and treatment to achieve optimal results. Topical therapy combining astaxanthin and PRP with wound debridement proved effective in this case.
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Changes in Retinal Ganglion Cell (RGC) and Retinal Nerve Fiber Layer (RNFL) Thickness in Children with Type 1 Diabetes Mellitus at Dr. M. Djamil General Hospital, Padang, Indonesia
Views: 578Downloads: 343Background: Type 1 diabetes mellitus (DM) is a chronic metabolic disorder that causes hyperglycemia and increases the risk of morbidity and mortality. Diabetic retinopathy, a microvascular complication that often occurs in DM patients, can cause visual impairment and even blindness. Regular eye examinations are important for early detection of diabetic retinopathy. Optical coherence tomography (OCT) is a non-invasive method that can be used to measure the thickness of retinal layers, including RGC and RNFL. It is thought that thinning of the retinal layer can be a sensitive biomarker in detecting diabetic retinopathy in type 1 DM patients. This study aims to determine changes in RGC and RNFL thickness in children with type 1 DM.
Methods: This cross-sectional design analytical observational study was conducted at the eye polyclinic of Dr. M. Djamil General Hospital Padang in November 2023-March 2024. A total of 46 eyes from 46 people, divided into two groups: the type 1 DM group and the control group, were recruited in this study. RGC thickness was measured using AS-OCT GC-IPL thickness analysis and RNFL with optic disc RNFL thickness analysis. Data analysis was carried out using the unpaired T-test.
Results: The results showed RGC depletion in the type 1 DM group (RGC 83.48 ± 3.75) compared to the control group (RGC 86.70 ± 4.87) with a value of p = 0.016 (p < 0.05). There was no statistical difference in RNFL thickness between the type 1 DM group (RNFL 102 ± 11.80) and the control group (RNFL 100.96 ± 10.97) with a value of p = 0.581 (p> 0.05).
Conclusion: This study found RGC thinning in type 1 DM patients, but did not find differences in RNFL thickness between the two groups. This RGC depletion is thought to be caused by apoptosis of retinal neuronal cells due to chronic hyperglycemia. Examination of RGC thickness with OCT can be developed as an early detection of diabetic retinopathy in children with type 1 DM.
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Overview of Characteristics of Parathyroid Tumor Patients at Dr. Hasan Sadikin General Hospital Bandung, Indonesia: A 5-Year Study
Views: 506Downloads: 349Background: Parathyroid tumors are the most common endocrine neoplasms, with hyperparathyroidism as the main clinical manifestation. Parathyroid adenoma is the most common benign neoplasm, while parathyroid carcinoma is relatively rare but difficult to differentiate from benign disorders. This study aims to describe the characteristics of parathyroid tumor patients at Dr. Hasan Sadikin General Hospital (RSHS) Bandung over the last 5 years.
Methods: This descriptive observational research was carried out by collecting medical record data from parathyroid tumor patients at RSHS Bandung for the 2019-2023 period. Parameters identified included age, gender, and histopathological type. Data analysis was carried out using SPSS univariately.
Results: There were 12 patients with parathyroid tumors with an increasing trend in cases over the last 5 years. The average age of patients was 37.33 years, with the majority (9 cases) being women. Parathyroid adenoma was the most common histopathological type (8 cases), followed by parathyroid carcinoma (2 cases), osteitis fibrocystica (1 case), and bone deformity (1 case). One patient with parathyroid adenoma was also diagnosed with fibrous dysplasia.
Conclusion: The majority of cases of parathyroid tumors at RSHS Bandung occur in women, with the incidence of parathyroid carcinoma being the same in men and women. Parathyroid adenoma is the most common histopathological type, and bone abnormalities complications can occur in patients with parathyroid disorders (3 patients).
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Effectiveness of Renal Denervation Therapy in Persistent Hypertension: A Meta-Analysis
Views: 611Downloads: 354Background: Persistent hypertension is a global health problem that requires effective therapy. Renal denervation (RDN) therapy is emerging as a promising new option. This meta-analysis aims to evaluate the effectiveness of RDN in patients with persistent hypertension.
Methods: We performed a systematic search in PubMed, Scopus, and the Cochrane Library for studies evaluating the effectiveness of RDN in patients with persistent hypertension. Data were extracted and analyzed using a random effects model.
Results: A total of 12 studies with a total of 1,024 patients were included in this meta-analysis. RDN demonstrated significant reductions in systolic and diastolic blood pressure compared with controls (MD -12.3 mmHg [95% CI -15.8 to -8.8] for systolic blood pressure and MD -6.1 mmHg [95% CI -8.2 to -4.0] for blood pressure diastolic). The effectiveness of RDN is higher in patients with more severe hypertension and in patients who are unresponsive to antihypertensive drugs.
Conclusion: RDN is an effective therapy for persistent hypertension, especially in patients with more severe hypertension and in patients who are unresponsive to antihypertensive drugs.
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Systemic Lupus Erythematosus with Lupus Nephritis, Community-Acquired Pneumonia, Bilateral Pleural Effusion, Pericardial Effusion, and Hypoalbuminemia in a 20-Year-Old Male Patient: A Case Report
Views: 1,260Downloads: 898Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem inflammation. Lupus nephritis is a serious complication of SLE that can cause kidney failure. Community acquired pneumonia (CAP), bilateral pleural effusion, pericardial effusion, and hypoalbuminemia are other complications that can occur in SLE patients.
Case presentation: We report the case of a 20-year-old man with SLE who presented with lupus nephritis, CAP, bilateral pleural effusion, pericardial effusion, and hypoalbuminemia. Patients were diagnosed with SLE based on the American College of Rheumatology (ACR) classification criteria. The diagnosis of lupus nephritis is made based on the presence of proteinuria, hematuria, and casts on urinalysis, as well as findings on kidney biopsy. CAP is diagnosed based on the presence of fever, cough, cough with phlegm, and infiltrates on chest X-ray. Bilateral pleural effusion and pericardial effusion were diagnosed based on physical examination and findings on chest ultrasound. Hypoalbuminemia is diagnosed based on low serum albumin levels. Patients are treated with steroids, antimalarials, diuretics, and antibiotics. The patient's symptoms improved and complications resolved.
Conclusion: SLE is a complex disease that can cause a variety of serious complications. Early diagnosis and treatment of these complications are essential to improve the patient's prognosis. This case shows that SLE can cause a variety of serious complications, including lupus nephritis, CAP, bilateral pleural effusion, pericardial effusion, and hypoalbuminemia. Early diagnosis and treatment of these complications are essential to improve the patient's prognosis.
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The Role of Antidepressants in a Malignancy Patient with Palliative Care: A Systematic Literature Review
Views: 623Downloads: 389Background: Depression is a common complication in malignancy patients, and can worsen their quality of life and prognosis. Palliative care aims to improve the quality of life of patients with life-limiting illnesses, and antidepressants are often used in this context.
Methods: This systematic review was conducted to evaluate the effectiveness of antidepressants in malignancy patients with palliative care. A literature search was conducted in three databases: PubMed, Cochrane, and ScienceDirect. Search terms included “Antidepressants,” “Malignancies,” and “Palliatives.”
Results: Two studies met inclusion criteria: First study: Randomized controlled clinical trial evaluating the effectiveness of mirtazapine compared with escitalopram in malignant patients with depression. The results showed that mirtazapine was more effective in improving quality of life and reducing depressive symptoms compared with escitalopram. Second study: a study evaluating the effectiveness of antidepressants in elderly malignancy patients with depression. The results suggest that antidepressants may be effective in reducing depressive symptoms and improving quality of life, but further research is needed to confirm their effectiveness and safety.
Conclusion: Available evidence suggests that antidepressants may be effective in treating depression in malignancy patients with palliative care. However, further research is needed to identify the most effective and safe antidepressants for this patient population.
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Idiopathic Pulmonary Fibrosis: A Narrative Literature Review
Views: 612Downloads: 478Idiopathic pulmonary fibrosis is a chronic progressive interstitial lung disease (ILD) with unknown causes. Male gender, age > 60 years, history of smoking with symptoms of dry cough and progressive chronic shortness of breath are typical clinical findings in this patient. The diagnosis is made based on a combination of radiological findings in the form of a pattern consistent with usual interstitial pneumonia (UIP) and/or histopathology with the exclusion of other causes of ILD. Treatment includes pharmacological and non-pharmacological therapy in the form of pulmonary rehabilitation, psychosocial support, and lung transplantation. Anti-fibrosis pharmacological therapy, namely nintedanib and pirfenidone, has been proven to slow the progression of pulmonary fibrosis and reduce mortality. The relatively low average survival rate of 3-4 years after the diagnosis is made makes this disease have a poor prognosis and requires adequate identification and treatment in order to reduce morbidity, mortality and improve the quality of life of sufferers.
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Study Analysis of Total Bilirubin Levels on Mortality in COVID-19 Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia
Views: 509Downloads: 303Background: Coronavirus Disease 2019 (COVID-19) is caused by a positive single-stranded RNA virus. The clinical manifestations of COVID-19 are not only dominated by respiratory tract symptoms but can also show symptoms of liver damage in severe COVID-19 patients. Liver damage that occurs can cause acute liver failure and result in death. Examination of liver damage marker parameters such as total bilirubin needs to be carried out as mortality increases in COVID-19 patients. This study aims to determine the relationship between total bilirubin levels and mortality in COVID-19 patients.
Methods: Cross-sectional analytical research was conducted on 40 COVID-19 patients treated at Dr. M. Djamil General Hospital Padang from July to December 2021. Examination of total bilirubin levels using the colorimetric diazo method. Bivariate analysis used the Mann-Whitney test to see the relationship between total bilirubin levels and mortality.
Results: The average age of the research subjects was 61.85 (1.40) years, with 65% men and 35% women. The mortality percentage in COVID-19 patients is 65%. The median total bilirubin level was 1.95 (0.5-2.8) mg/dL. The relationship between total bilirubin levels and mortality in COVID-19 patients was found to have a p-value of <0.001. The study results showed that the median total bilirubin level in COVID-19 patients who died was relatively higher, namely 2.20 (1.4-2.8) mg/dL, compared to those who did not die, namely 0.70 (0.5-1. 6) mg/dL.
Conclusion: The results of this study show that there is a relationship between total bilirubin levels and mortality in COVID-19 patients.
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Differences in Carcinoembryonic Antigen (CEA) Levels Based on the Degree of Histopathological Differentiation of Colorectal Cancer: Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia
Views: 893Downloads: 401Background: Colorectal cancer is the third malignancy and second leading cause of death in the world. CEA levels before surgery can be used as a cancer marker to help staging, planning, monitoring therapy and disease recurrence. One factor that influences CEA levels is the degree of differentiation of cancer cells. This study aims to determine differences in CEA levels based on the degree of histopathological differentiation in colorectal cancer patients at Dr. M. Djamil General Hospital Padang.
Methods: This study was a cross-sectional analytical observational study using medical record data from colorectal cancer patients from January 2021 – August 2023. The sample was 65 patients who met the inclusion and exclusion criteria. CEA examination uses the ELFA method. The Mann Whitney test was used to see differences in CEA levels based on the degree of differentiation, statistically significant if p < 0.05.
Results: A total of 65 patients with an average age of 56.89 years, 58.5% men, 41.5% women. A total of 10 patients were stage I, 29 stage II, and 26 stage III. Based on histopathology, 50 patients were classified as low grade and 15 as high grade. Low-grade CEA levels were 67.72 (3.14-200) ng/mL, while high grade were 3.2 (0.57-11.42) ng/mL. There was a significant difference in CEA levels based on histopathological differentiation (p < 0.001).
Conclusion: CEA levels are higher in low-grade than high-grade colorectal cancer.
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Overview of Bacterial Profile of Bloodstream Infections in the Intensive Care Unit (ICU): Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia
Views: 553Downloads: 310Background: Bloodstream infection (BSI) is a condition characterized by positive blood cultures in patients who have systemic infections. Bloodstream infections have developed into a threat to public health worldwide with high mortality rates in intensive care settings. This study aims to determine the bacterial profile of BSI in the intensive care unit (ICU) of Dr. M. Djamil General Hospital Padang.
Methods: This study is a retrospective descriptive study with a cross-sectional design from secondary data at the Microbiology and Medical Records Installation Laboratory of Dr. M. Djamil General Hospital Padang. All blood samples from patients aged ≥18 years in the ICU who are suspected of being infected will be cultured and identified with VITEK 2 in 2022.
Results: A total of 243 blood samples consisted of 126 men (52%) and 117 women (48%) with the largest age range being 41-60 years (48%). The diagnosis of BSI was found in 94% with the most common comorbidities being malignancy (42%) and stroke (15%). The most common bacterial bloodstream infections were found in the ICU of Dr. M. Djamil General Hospital Padang., namely Gram-positive bacteria (66%) and coccus (66%). The most common type of bacteria identified with the VITEK 2 automatic tool is Staphylococcus hominis. Multidrug-resistant organisms (MDRO) found in this study were 8% with the most common causes, namely extended spectrum B-lactamase (ESBL). Blood samples in this study found bacteria due to contamination by 38%.
Conclusion: The BSI bacterial profile found was mostly in the ICU of Dr. M. Djamil General Hospital Padang is a Gram-positive bacterium, coccus-shaped, Staphylococcus hominis and ESBL. Blood cultures found bacteria contaminated by 38%.
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Differences in D-Dimer Levels in Acute Ischemic and Hemorrhagic Stroke: Observational Study in the Emergency Department of Dr. M. Djamil General Hospital, Padang, Indonesia
Views: 1,011Downloads: 625Background: Stroke is the second largest cause of death worldwide with a high morbidity rate of up to 50% of survivors get chronic disability. Rapid diagnosis in patients with suspected acute ischemic or hemorrhagic stroke is very important to determine management and prognosis. D-dimer is an indirect marker of fibrinolysis which functions as a significant marker of activation of coagulation and fibrinolysis. This study aims to determine the differences in D-dimer levels in ischemic and acute hemorrhagic stroke patients in the emergency room (ER) of Dr. M. Djamil General Hospital Padang.
Methods: Analytical observational research by cross-sectional design was carried out on 56 samples consisting of 28 acute ischemic and 28 acute hemorrhagic stroke samples for the period December 2022-June 2023. D-dimer levels and CTscan checked on each group and analysis is carried out.
Results: The most common characteristics of research subjects were men, namely 35 patients (62.5%) and aged 51-60 years (32.1%). The mean D-dimer levels for ischemic and hemorrhagic strokes were 794.33 ng/mL (±2.63) and 1288.25 ng/mL (±2.51) with a p-value = 0.055.
Conclusion: The mean D-dimer in acute hemorrhagic stroke was higher than in acute ischemic stroke but there was no statistically significant difference. The D-dimer examination cannot differentiate the type of stroke that occurred.
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Estimated Glomerular Filtration Rate in Pediatric Patients with β-Thalassemia Major: A Single-Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia
Views: 560Downloads: 475Background: Patients with β-thalassemia major can experience impaired kidney function. Impaired kidney function can occur without symptoms and before serious manifestations appear, so early markers are needed to detect kidney damage. Estimated glomerular filtration rate (eGFR) is a calculation to detect early impairment of kidney function and is widely accepted as an indicator in determining overall kidney function. This study aims to determine the estimated glomerular filtration rate in pediatric patients with β-thalassemia major.
Methods: This research is a descriptive research. Data was taken from pediatric patients with β-thalassemia major who received routine transfusions at the pediatric polyclinic of Dr. M. Djamil General Hospital Padang from January 1st – July 31st 2023. Patients underwent hematology examination, serum ferritin, serum creatinine, and estimated glomerular filtration rate calculations using the Schwartz formula.
Results: A total of 55 children met the research criteria, consisting of 27 boys (49%) and 28 girls (51%). The median serum creatinine level was 0.5 (0.3-0.8) mg/dL with a range with a mean estimated glomerular filtration rate of 167 mL/minute/1.73m2.
Conclusion: Glomerular hyperfiltration occurs in the majority of β-thalassemia major patients, but a decrease in
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Overview Profile of High Sensitive Troponin I (hsTnI) Levels Based on Infarction Location in Acute Myocardial Infarction Patients: A Single Center Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia
Views: 563Downloads: 365Background: Acute myocardial infarction (AMI) remains an important health problem globally. A diagnosis of AMI can be made by finding at least two of the three criteria, namely typical angina pain, electrocardiography (ECG) abnormalities, and increased cardiac biomarkers. Variations in troponin levels based on examination time and infarct location were obtained from previous studies. High-sensitive troponin I (hsTnI) is a very specific biomarker in detecting myocardial damage. This study aims to determine the description of hsTnI levels based on the location of the infarction in AMI patients of Dr. M. Djamil General Hospital Padang. The location of the infarction in AMI determines the management and prognosis for the clinician.
Methods: This research is a retrospective study with a cross-sectional design at the Laboratory Installation of Dr. M. Djamil General Hospital Padang. The sample was adult patients diagnosed with AMI with complete data that met the inclusion and exclusion criteria, taken from medical records.
Results: This study showed that from a total of 140 AMI patients, 67 samples met the inclusion criteria. A total of 67 AMI patients consisted of 59 men (88.06%) and 8 women (11.94%) with an average age of 60.1 + 10.5 years. The highest hsTnI levels were found at the posterior infarction location, 40,000 ng/L (16,639-48,997). The location of the infarction was dominated by the inferior infarction location in 20 people (29.9%).
Conclusion: The highest hsTnI levels were found at the posterior infarction location. The location of the infarction is dominated by the inferior infarction location in AMI patients with ST elevation at Dr. M. Djamil General Hospital Padang.
