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Abstract
A B S T R A C T
Introduction. Preeclampsia is one of the leading causes of maternal and perinatal
morbidity and mortality and is still a disease of theory. Klotho is a new gene, in
several biological processes in the pathophysiology of preeclampsia that play a role
in regulating endothelial nitric oxide production, angiogenesis, production of
antioxidant enzymes and protection against endothelial dysfunction. The Klotho G-
395A genotype AA promoter polymorphism is the cause of hypertension. This study
aims to determine the relationship of the Klotho G-395A promoter polymorphism to
the incidence of preeclampsia. Methods. This study is an analytical study with a
case-control design. The research was conducted at Pembina community health
centre of Palembang and the public hospital of Prabumulih in February - July 2020
and involving 50 case group and 50 control group. To determine the genotype and
allotype of the Klotho G-395A gene promoter polymorphism, using polymerase chain
reaction examination. Result. The results showed that the risk factors for maternal
age and maternal gestational age had a significant relationship with the incidence of
preeclampsia (p-value 0.015; p-value 0.000). There was a significant relationship
between the Klotho G-395A genotype GA + AA promoter polymorphism and the
incidence of preeclampsia (p-value 0.024; OR = 2.571; 95% CI = 1.122-5.895), while
allotypes in the study sample also had a significant relationship with the incidence
of preeclampsia. preeclampsia (p-value 0.025; OR = 1.978; 95% CI = 1.087-3.599).
Conclusion: There is a significant relationship between the Klotho G-395A gene
promoter polymorphism and the incidence of preeclampsia.
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