The Effect of Vitamin D Supplementation on the Increase in CD4 count of HIV/AIDS Patients Receiving Antiretroviral Therapy
DOI:
https://doi.org/10.32539/bsm.v5i1.186Keywords:
Vitamin D, Calcitriol, CD4 Count, HIV, Antiretroviral DrugsAbstract
Introduction. Vitamin D plays a role in health overall, but hypovitaminosis D still
occurs throughout the world. HIV/AIDS patients are prone to suffer from
hypovitaminosis D because of the infection itself and the side effects of antiretroviral
therapy. Various effort have been tried to improve the immune status of HIV/AIDS
patients, one of them is by adding vitamin D. Vitamin D acts as an antiinflammatory
so that it can prevent apoptosis of CD4 T cells and increase CD4 cell count.
Methods. This is a randomized control trial add on a study that aims to determine
the effect of vitamin D to increase in CD4 counts of HIV / AIDS patients who have
received antiretroviral drugs. Subjects were HIV / AIDS patients who had received
antiretroviral drugs. A total of 20 subjects were divided randomly into two groups;
one group received vitamin D (calcitriol 0.5 mcg per day) for eight weeks, and the
other group that received a placebo. Each group was measured of CD4 cell count
before and after treatment. Results. There was a significant increase in the CD4 cell
count of the vitamin D group (p = 0.046), but not in the CD4 cell count of both
groups (p = 0.985). The comparison of mean CD4 cell counts between groups before
treatment was not significantly different (p = 0.057), but after treatment, it became
significantly different (p = 0.040). Conclusion. Vitamin D has been successful in
increasing CD4 cell count in the vitamin D group, and it is recommended to give
HIV / AIDS patients to increase CD4 cell count.
Authors
- Mega Permata1*
- Harun Hudari1
- Mediarty1
- Taufik Indrajaya1
- 1Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Corresponding author Mega Permata — megaramdja73@gmail.com
Article history
- Submitted
- Accepted
- Published
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