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Abstract
A B S T R A C T
Introduction. Acute kidney injury (AKI) is defined as sudden decline in the
glomerular filtration rate, resulting in the retention of nitrogenous wastes, such as
urea and creatinine in plasma. Cinnamomum burmannii is known as a anti-
inflammatory renoprotective agent, although the precise mechanism is not well
understood. This study aimed to elucidate the effectiveness of Cinnamomum
burmannii extract in decreasing creatinine level of acute kidney injury Ischemia
reperfusion (IR) model. Method. We performed Ischemia reperfusion (IR) in male
Wistar rat to induce acute kidney injury. The rat (n=30) were divided into six groups:
IR, 1 group treated with methylprednisolone as a control (IR+M), 3 groups treated
with different oral Cinnamomum burmannii extract doses (50mg/kg (IR+EKM1),
100mg/kg (IR+EKM2), and 200 mg/kg (IR+EKM3), and a Sham operation (SO)
group. AKI stage reduction based on serum creatinine levels, before and after
modeling, before and after the cinnamon extract intervention. Creatinine levels were
quntified by spectrophotometry and analyzed by SPSS. Result. Cinnamomum
burmannii extract lowers creatinine levels; significant (P <0.05). 200 mg / kgbb is
the effective dose of lowering creatinine levels in the IR model. Conclusion.
Cinnamomum burmannii extract reduced serum creatinine levels associated with
decreased acute renal staging in the IR model.
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