Dermatoglyphy in Breast Cancer Patients: A Systematic Review
DOI:
https://doi.org/10.32539/bsm.v5i11.368Keywords:
Breast Neoplasms, Pregnancy, Human BRCA2 Protein, Mutation, EstrogenAbstract
Background. Breast cancer is one of the four types of cancer among women and is the most frequently diagnosed in most countries. Breast cancer occurs due to DNA damage and genetic mutations affected by exposure to estrogen, inheritance of damaged DNA, or pro-cancer genes such as BRCA1 and BRCA2. Therefore, a family history of ovarian cancer or breast cancer increases the risk of developing breast cancer. The embryo of the breast develops around the age of 6 weeks of pregnancy. Similar to breast development, fingerprint patterns also develop during the 6-13 weeks of pregnancy. Thus, the genetic message contained in the genome occurred during that period and was reflected in the dermatoglyphic pattern.
Methods. The literature search was systematically used using PubMed, Cochran, Google scholar, and other Gray literature between 2010-2020. Of the 69 publications identified, 21 met the criteria and were included in the review. The review is carried out following the provisions of PRISMA (Preferred Reporting Items for Systematic Review).
Results. This systematic review showed fairly consistent findings in breast cancer patients who tended to have more whorl fingerprint patterns and larger ATD angles. For radial loops, ulnar loops and arches were minor compared to the control group potential as an initial screening tool in at-risk groups.
Conclusion. Long-term and follow-up studies with larger sample sizes in various ethnicities are needed to validate dermatoglyphics in anthropometric measurements as a promising marker of breast cancer.
Authors
- Rara Inggarsih1*
- Akhyar Dyni Zakyah2
- Lusia Hayati 1
- Joko Marwoto 1
- Septi Purnamasari1
- Arwan Bin Laeto3
- Masayu Farah Diba4
- 1Department of Biology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
- 2Department of Dentistry, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
- 3Department of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
- 4Department of Microbiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Corresponding author Rara Inggarsih — rarainggarsih@fk.unsri.ac.id
Article history
- Submitted
- Accepted
- Published
Downloads
Published
Issue
Section
License
Copyright and licensing
Copyright in each article remains with the author(s). Authors grant Bioscientia Medicina: Journal of Biomedicine and Translational Research a non-exclusive right of first publication and the right to identify itself as the original publisher. No exclusive transfer of copyright is required.
All articles are published under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0): https://creativecommons.org/licenses/by-nc-sa/4.0/. Users may copy, redistribute, remix, transform, and build upon the material for non-commercial purposes, provided appropriate attribution is given, a link to the license is supplied, changes are indicated, and adaptations are distributed under the same license.
The license applies to the article's scholarly content unless a credit line states otherwise. Third-party material may be subject to separate rights. Authors retain patent, trademark, moral, and research-data rights. The copyright year follows the article's publication date.
