Coronary Microvascular Dysfunction
DOI:
https://doi.org/10.32539/bsm.v5i12.428Keywords:
Coronary Microvascular Dysfunction, Mechanism, Diagnostic Test, TreatmentAbstract
Coronary microvascular dysfunction (DMK) is a condition of patients who are accompanied by complaints of chest pain where the results of coronary angiography examination are normal and this is almost 49% with 60% of patients diagnosed with DMK. Another study said that about 40% of patients with DMK showed coronary flow reserve (CFR <2) of about 40% and the WISE study (Women's Ischaemia Syndrome Evaluation) showed that about 47% of patients with chest pain had normal coronary arteries. DMK can be divided into 4 groups; DMK with no coronary arterial disease (CAD) obstruction and myocardial disease, DMK with myocardial disease where this occurs due to remodeling of intramural coronary arteries, DMK with CAD (coronary arterial disease) or acute myocardial infarction with or without ST segment, iatrogenic typhoid DMK occurs after coronary recanalization caused by vasoconstriction and distal embolization. The mechanism of action of DMK can be caused by several factors, namely endothelial dysfunction, smooth muscle dysfunction, decreased diastolic perfusion time, damage to blood vessels and damage to the vascular and microvascular remodeling. And to enforce this DMK, there are several tests carried out in diagnosing the disease, some of which are invasive and non-invasive so that by enforcing the diagnosis of this disease, treatment for DMK can be done immediately and optimally.
Authors
- Doharjo Manullang1*
- Imran Soleh2
- Rukiah Chodilawati2
- Syamsu Indra2
- Ferry Usnizar2
- Erwin Sukandi2
- Taufik Indrajaya2
- Ali Ghanie2
- 1Subspesialized Training, Cardiovascular Division, Department Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
- 2Cardiovascular Division, Department Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Corresponding author Doharjo Manullang — doharjomanullang@yahoo.com
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