Main Article Content

Abstract

Background. Disruption to the healing process of these wounds will consume large resources and will often require long-term medical management. Aloe vera oil is rich in anthraquinone compounds, especially emodin and chrysophanol. Anthraquinones have potent anti-inflammatory effects, which have the potential to activate various growth factors and chemokines and initiate angiogenesis processes that play a major role in wound healing. The ability of ozone to trigger mild oxidative stress plays an important role in triggering a cascade of cytokines and chemokines, including the initiation of vascular endothelial growth factor (VEGF) proteins that play a role in the initiation of angiogenesis.


Methods: This study is an in vivo experimental study. A total of 60 rats were divided into 10 treatment and control groups. The treatment group was given ozonized aloe vera oil 600 mg/mL, 1200 mg/mL and 1800 mg/mL. Furthermore, the assessment of VEGF and new blood vessel formation was carried out. Data analysis was performed using SPSS version 25 software with univariate and bivariate tests.


Results: The administration of ozonized aloe vera oil was able to increase the expression of VEGF, and the number of new blood vessels in the excision wound tissue.


Conclusion: Ozonized aloe vera oil is effective in promoting excision wound tissue repair in vivo.

Keywords

Aloe vera oil Ozonization VEGF Angiogenesis

Article Details

How to Cite
Gunawan, E. S., Muhamad Thohar Arifin, Yuriz Bakhtiar, Yan Wisnu Pradjoko, & Muhammad Nur. (2022). Effects of Ozonized Aloe Vera Oil on Full-Thickness Excision Wound Healing: In Vivo Study. Bioscientia Medicina : Journal of Biomedicine and Translational Research, 6(10), 2248-2253. https://doi.org/10.37275/bsm.v6i10.588