Effects of Ozonized Aloe Vera Oil on Full-Thickness Excision Wound Healing: In Vivo Study
DOI:
https://doi.org/10.37275/bsm.v6i10.588Keywords:
Aloe vera oil, Ozonization, VEGF, AngiogenesisAbstract
Background. Disruption to the healing process of these wounds will consume large resources and will often require long-term medical management. Aloe vera oil is rich in anthraquinone compounds, especially emodin and chrysophanol. Anthraquinones have potent anti-inflammatory effects, which have the potential to activate various growth factors and chemokines and initiate angiogenesis processes that play a major role in wound healing. The ability of ozone to trigger mild oxidative stress plays an important role in triggering a cascade of cytokines and chemokines, including the initiation of vascular endothelial growth factor (VEGF) proteins that play a role in the initiation of angiogenesis.
Methods: This study is an in vivo experimental study. A total of 60 rats were divided into 10 treatment and control groups. The treatment group was given ozonized aloe vera oil 600 mg/mL, 1200 mg/mL and 1800 mg/mL. Furthermore, the assessment of VEGF and new blood vessel formation was carried out. Data analysis was performed using SPSS version 25 software with univariate and bivariate tests.
Results: The administration of ozonized aloe vera oil was able to increase the expression of VEGF, and the number of new blood vessels in the excision wound tissue.
Conclusion: Ozonized aloe vera oil is effective in promoting excision wound tissue repair in vivo.
Authors
- Evan Sebastian Gunawan1*
- Muhamad Thohar Arifin2
- Yuriz Bakhtiar2
- Yan Wisnu Pradjoko3
- Muhammad Nur4
- 1Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Department of General Surgery Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital, Semarang, Indonesia
- 2Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Department of Neurosurgery Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital, Semarang, Indonesia
- 3Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Department of Oncology Surgery, Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital, Semarang, Indonesia
- 4Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Center for Plasma Research, Department of Physics, Faculty of Science and Mathematics, Universitas Diponegoro, Semarang, Indonesia
Corresponding author Evan Sebastian Gunawan — evansgunawan@gmail.com
Article history
- Submitted
- Accepted
- Published
Downloads
Published
Issue
Section
License
As our aim is to disseminate original research article, hence the publishing right is a necessary one. The publishing right is needed in order to reach the agreement between the author and publisher. As the journal is fully open access, the authors will sign an exclusive license agreement.
The authors have the right to:
- Share their article in the same ways permitted to third parties under the relevant user license.
- Retain copyright, patent, trademark and other intellectual property rights including research data.
- Proper attribution and credit for the published work.
For the open access article, the publisher is granted to the following right.
- The non-exclusive right to publish the article and grant right to others.
- For the published article, the publisher applied for the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
