Effects of Ozonized Aloe Vera Oil on Full-Thickness Excision Wound Healing: In Vivo Study
DOI:
https://doi.org/10.37275/bsm.v6i10.588Keywords:
Aloe vera oil, Ozonization, VEGF, AngiogenesisAbstract
Background. Disruption to the healing process of these wounds will consume large resources and will often require long-term medical management. Aloe vera oil is rich in anthraquinone compounds, especially emodin and chrysophanol. Anthraquinones have potent anti-inflammatory effects, which have the potential to activate various growth factors and chemokines and initiate angiogenesis processes that play a major role in wound healing. The ability of ozone to trigger mild oxidative stress plays an important role in triggering a cascade of cytokines and chemokines, including the initiation of vascular endothelial growth factor (VEGF) proteins that play a role in the initiation of angiogenesis.
Methods: This study is an in vivo experimental study. A total of 60 rats were divided into 10 treatment and control groups. The treatment group was given ozonized aloe vera oil 600 mg/mL, 1200 mg/mL and 1800 mg/mL. Furthermore, the assessment of VEGF and new blood vessel formation was carried out. Data analysis was performed using SPSS version 25 software with univariate and bivariate tests.
Results: The administration of ozonized aloe vera oil was able to increase the expression of VEGF, and the number of new blood vessels in the excision wound tissue.
Conclusion: Ozonized aloe vera oil is effective in promoting excision wound tissue repair in vivo.
Authors
- Evan Sebastian Gunawan1*
- Muhamad Thohar Arifin2
- Yuriz Bakhtiar2
- Yan Wisnu Pradjoko3
- Muhammad Nur4
- 1Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Department of General Surgery Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital, Semarang, Indonesia
- 2Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Department of Neurosurgery Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital, Semarang, Indonesia
- 3Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Department of Oncology Surgery, Faculty of Medicine, Universitas Diponegoro/Dr. Kariadi General Hospital, Semarang, Indonesia
- 4Biomedical Science Master Program Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia/Center for Plasma Research, Department of Physics, Faculty of Science and Mathematics, Universitas Diponegoro, Semarang, Indonesia
Corresponding author Evan Sebastian Gunawan — evansgunawan@gmail.com
Article history
- Submitted
- Accepted
- Published
Downloads
Published
Issue
Section
License
Copyright and licensing
Copyright in each article remains with the author(s). Authors grant Bioscientia Medicina: Journal of Biomedicine and Translational Research a non-exclusive right of first publication and the right to identify itself as the original publisher. No exclusive transfer of copyright is required.
All articles are published under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0): https://creativecommons.org/licenses/by-nc-sa/4.0/. Users may copy, redistribute, remix, transform, and build upon the material for non-commercial purposes, provided appropriate attribution is given, a link to the license is supplied, changes are indicated, and adaptations are distributed under the same license.
The license applies to the article's scholarly content unless a credit line states otherwise. Third-party material may be subject to separate rights. Authors retain patent, trademark, moral, and research-data rights. The copyright year follows the article's publication date.
