Effects of Pancreatic Omentoplasty on Diabetes Mellitus with Obesity after Sleeve Gastrectomy: An In Vivo Study
DOI:
https://doi.org/10.37275/bsm.v6i10.592Keywords:
Obesity, Diabetes mellitus, Sleeve gastrectomy, Pancreatic omentoplastyAbstract
Background: DM, especially type 2 diabetes mellitus (DMT2), is closely related to obesity. Insulin resistance and inflammation that occur in obese patients can be treated with SG procedures. Post-SG weight loss can reduce the lipo apoptotic process and can improve the function of pancreas β cells. The omentum is rich in potential mesenchymal stem cells and is rich in anti-inflammatory cytokines, and various growth factors, so the omentoplasty procedure is believed to be able to provide a regenerating effect on the pancreatic tissue so that the performance of the pancreas can be optimal.
Methods: An experimental study with 18 rats which were divided into control and treatment groups. The treatments were sleeve gastrectomy and pancreatic omentoplasty. Furthermore, analysis of body weight and levels of IL-10 and HOMA IR was carried out with the help of SPSS software version 25 univariate and bivariate.
Results: There was a difference in mean body weight, levels of IL-10, and HOMA IR before and after treatment, p<0.001.
Conclusion: Omentoplasty is effective in improving the condition of diabetes mellitus with obesity after sleeve gastrectomy surgery in vivo.
Authors
- Indra Kusuma Adi Putranto1*
- K. Heri Nugroho2
- Abdul Mughni3
- 1Specialized Residency Training, Department of Surgery, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
- 2Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
- 3Division of Digestive Surgery, Department of Surgery, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Corresponding author Indra Kusuma Adi Putranto — indrakaputranto@gmail.com
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