The Differences in Indoleamine 2,3-dioxygenase 1 Plasma Activity of HIV-Positive Pulmonary Tuberculosis and HIV-Negative Pulmonary Tuberculosis
DOI:
https://doi.org/10.37275/bsm.v6i14.659Keywords:
HIV, IDO1, Infection, K/T ratio, Lung tuberculosisAbstract
Background: Tuberculosis is the most common cause of death in HIV patients. Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that plays a crucial role in the immune response to TB and HIV infection. Increased plasma IDO1 activity in TB patients can be a promising marker for the diagnosis of TB, especially in HIV patients. This study aimed to evaluate the differences in the activity of indoleamine 2,3-dioxygenase 1 plasma of HIV-positive pulmonary TB with HIV-negative pulmonary TB patients.
Methods: This study is an analytic observational study. Plasma IDO1 activity was assessed by calculating the kynurenine/tryptophan ratio (K/T ratio). This indicator was assessed on 28 lung TB patients divided into two groups, HIV-positive pulmonary TB and HIV-negative pulmonary TB group.
Results: Twenty-eight subjects were included in this study with a mean age of 42,96 (16,17) years, with more males than females. This study's mean K/T ratio was 0.18 (0.16), with HIV-positive pulmonary TB is higher than HIV-negative pulmonary TB (0.24 vs 0.12, p = 0.027).
Conclusion: There is a significant difference in the Indoleamine 2,3-dioxygenase 1 (IDO1) plasma in HIV-positive pulmonary TB and HIV-negative pulmonary TB groups. Thus the IDO1 plasma can be used as a new biomarker in diagnosed TB in HIV patients.
Authors
- Roza Kurniati1*
- Dwitya Elvira2
- Rido Wandrivel3
- 1Division of Pulmonology, Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
- 2Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
- 3Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Corresponding author Roza Kurniati — dr_rozakurniati@yahoo.com
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- Submitted
- Accepted
- Published
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