Hypertension as Comorbidity in Pemphigus Vulgaris Patients: A Case Series
DOI:
https://doi.org/10.37275/bsm.v6i11.607Keywords:
Bullous diseases, Hypertension, Pemphigus vulgarisAbstract
Background: Pemphigus Vulgaris (PV) is a chronic autoimmune bullous disease characterized by flaccid blisters on the skin and mucous membrane. This study aimed to report a serial case of PV followed by hypertension as comorbidity.
Case presentation: Four patients, 2 males, and 2 females were hospitalized due to PV. All of these patients also suffer from hypertension, but only 2 patients take antihypertension. Drugs relatively, histopathology features of all patients revealed a cleft above the basal epidermal layer with a tombstone appearance. Pemphigus vulgaris can be accompanied by hypertension as comorbidity, but its pathogenesis is unclear. A low level of programmed cell death 1 (PD1) in PV patients promotes downregulating protective factors, including T regulator (Treg) cells. In addition, decreasing the PD1 level may cause apoptosis and inflammation process in the vascular endothelial, which may lead to hypertension.
Conclusion: Pemphigus vulgaris is significantly associated with hypertension.
Authors
- Bobby Febrianto1*
- Lian Kamilah1
- Fanny Fauziyyah Heryadi1
- Azhar Arrosyid1
- Nurrachmat Mulianto1
- 1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sebelas Maret/Dr. Moewardi General Hospital, Surakarta, Indonesia
Corresponding author Bobby Febrianto — bobbyf100289@gmail.com
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