Accreditation
SINTA 2Nationally Accredited Journal
Vol. 6 No. 13 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Articles
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The Role of Topical Vitamin D in Vitiligo: A Narrative Literature Review
Views: 1,869Downloads: 1,101Vitamin D plays a role in the process of melanogenesis, namely increasing L-Dopa cells, inducing differentiation of immature melanocytes, and increasing melanocyte activity. The use of vitamin D in dermatology is in the treatment of vitiligo, psoriasis vulgaris, atopic dermatitis, verruca vulgaris, and alopecia. Vitiligo is an autoimmune disease of the skin in the form of depigmentation due to the destruction of melanocytes by T cells. The clinical manifestations of vitiligo are white macular lesions and no scale, asymptomatic, and symmetrical. Vitiligo can affect the patient's quality of life, so accurate therapy is needed. Standard therapy in vitiligo needs further research to find accurate therapy with minimal side effects. Topical vitamin D is a vitiligo therapy with minimal side effects. Several types of topical vitamin D with therapeutic effects in the field of dermatology are calcipotriol, calcitriol, tacalcitol, maxacalcitol, and hexafluoro-1,25 dihydroxyvitamin D3 with various dosages and preparations. The role of vitamin D in melanogenesis and immunomodulators as monotherapy or in combination with topical corticosteroids has been shown to be effective in the treatment of vitiligo. This literature review was on the role of topical vitamin D in the treatment of vitiligo.
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Evaluation of the Dengue Hemorrhagic Fever Eradication Program in Palembang
Views: 869Downloads: 589Background: Dengue Haemorrhagic Fever (DHF) has the potential to cause Extraordinary Events (KLB), hence the government has made efforts to control DHF, one of which is through the PSN program. Evaluation is necessary to determine how the implementation of the PSN program is following the planned objectives and whether the program can control the breeding of mosquito larvae to reduce the number of dengue cases in Palembang City.
Methods: This study utilized a qualitative method with an analytical descriptive approach. The CIPP evaluation model was used to evaluate the context, input, process, and product to determine the success of the PSN program. The information was obtained from twelve informants who were recruited by purposive sampling.
Results: The study data was collected in the form of interviews, observations, and a document review to evaluate the dengue fever mosquito nest eradication program (PSN) in Palembang City in 2022. In general, the PSN program has gone well but is still constrained by budget. Furthermore, SOPs related to eradicating mosquito nests do not yet exist and there is a lack of community participation.
Conclusion: It is anticipated that Palembang City Health Office can use these study findings as a basis to justify budget allocation for the mosquito nest eradication program and develop SOPs regarding the eradication of mosquito nests to facilitate the program. They could also improve coordination, participation, and community empowerment to implement a larva-free village competition and providing a reward for villages that have been declared larva-free by the Puskesmas to encourage community participation in the eradication of mosquito nests.
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Morbus Hansen Multibacillary Type Mid Borderline: A Case Report
Views: 2,404Downloads: 1,641Background: Morbus Hansen (MH) is a granulomatous infectious disease caused by an obligate intracellular pathogenic bacterium, Mycobacterium leprae (M. leprae). Cardinal signs of Hansen's morbus (MH) include patches of numb skin, thickening of the peripheral nerves, and acid-fast bacteria (AFB) on a skin smear or biopsy. This case report aims to establish the diagnosis of mid borderline (BB) MH with clinical and histopathological examination.
Case presentation: A 44-year-old woman presented with red patches on her face and body 1 month ago. Madarosis and multiple erythematous plaques confluent, poorly demarcated, raised edges, atrophic center with some smooth shiny and some rough surfaces found in the facial region and superior extremities et al. bilateral inferior with bilateral auricular infiltrates. A sensory examination of the lesion showed decreased sensitivity to pain and temperature. Skin-slit smear examination showed AFB with bacterial index (IB) +2 and morphological index (IM) 30%. On histopathological examination with hematoxylin and eosin staining, Grenz zone appeared, epithelioid granuloma affecting the epidermis, no lymphocytes, and no giant Langhans cells were found, and nerves were surrounded by lymphocytes and granulomas. On fite-faraco staining, BTA was obtained with IB +3 and IM 30%. The diagnosis of MH type BB was established, and the patient was given multidrug therapy (MDT) multibacillary (MB).
Conclusion: Morbus Hansen type BB has a typical histopathological picture of granulomas composed of mature epithelioid cells, Grenz zone, AFB, enlarged and swollen nerves surrounded by lymphocytes or infiltrated with granulomas without damage. After 3 months of therapy, there was a decrease in IB and IM on AFB examination.
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Serum Vitamin D Levels Related to Cognitive Function in Chronic Kidney Disease Patients
Views: 620Downloads: 405Background: Vitamin D acts as a neuroprotector and modulator in the central nervous system. Hypovitaminosis is a risk factor for cognitive dysfunction. Hypovitaminosis D and impaired cognitive function are common in patients with chronic kidney disease. Impaired cognitive function is comorbid that can increase the morbidity and mortality of patients with chronic kidney disease. This study aims to assess the relationship between serum vitamin D levels and cognitive function in patients with chronic kidney disease.
Methods: This research is an observational study with a cross-sectional approach. A total of 60 research subjects participated in this study. Sociodemographic data, cognitive function, and vitamin D levels were analyzed in this study. Data analysis was performed with SPSS 25 to perform univariate and bivariate tests.
Results: The impaired cognitive function was found in 56.7% of CKD patients. The median serum vitamin D level of patients with chronic kidney disease with impaired cognitive function was 30.80 ng/mL and without impaired cognitive function 42.98 ng/mL. There was a significant relationship between serum vitamin D levels and impaired cognitive function (OR=4.125, p=0.035). The cut-off point of serum vitamin D levels associated with impaired cognitive function in CKD patients was 34.8 ng/mL (sensitivity 64.7% and specificity 69.2%).
Conclusion:There is a significant relationship between serum vitamin D levels and the incidence of cognitive dysfunction in patients with chronic kidney disease. The cut-off point for serum vitamin D levels associated with impaired cognitive function in chronic kidney disease is 34.8 ng/mL.
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The Role of Psychological Stress in Psoriasis: A Narrative Literature Review
Views: 1,229Downloads: 569Psoriasis is a chronic, persistent skin disease characterized by characteristic lesions in the form of well-defined erythematous patches covered by thick white, shiny scales resembling wax droplets. Psoriasis has a psychological, social, and emotional impact. Psychological stress has also been shown to influence the disease and course of psoriasis. Therapy in psoriasis patients with psychological stress can be given pharmacologically and psychologically. Patients with moderate to severe psoriasis using the Goeckerman regimen for psoriasis showed significant improvements in anxiety and depression scores. Psychological therapies such as relaxation therapy and meditation are able to control the emotions that trigger stress and reduce the appearance and severity of psoriasis. This literature review aims to describe the impact of psychological stress on psoriasis patients so as to increase awareness to detect psychological stress and provide appropriate treatment.
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Diagnosis and Treatment of Multibacillary Leprosy Borderline Lepromatous Type: A Case Report
Views: 1,068Downloads: 625Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. This disease has a high transmission ability and can cause physical disability and have an impact on the social life of the sufferer because of the negative stigma about leprosy. This study aims to describe the examinations performed in the diagnosis and treatment of patients with multibacillary leprosy, borderline lepromatous type.
Case presentation: A 43-year-old woman with a chief complaint of redness on the arm since 1 year ago. The patches are not itchy, painless, stiff, and numb. Since 3 months ago, the patient complained of red patches increasing and spreading to the trunk and legs. Dermatological examination found in the facial region et truncus anterior et posterior et superior, and inferior extremities bilateral showing multiple erythematous plaques, well-demarcated with scales in several parts. Sensory function examination revealed a decrease in lesions on the face, superior and inferior extremities, and anterior and posterior trunks. Negative AFB examination and biopsy results support the diagnosis of borderline lepromatous type (BL) multibacillary leprosy (MB).
Conclusion: Clinical findings in the form of hypopigmented lesions that feel numb is a cardinal signs of leprosy. Asymmetrical distribution of lesions with a number of more than 5 lesions accompanied by impaired nerve function in the form of decreased sensibility is a characteristic of MB leprosy. Histopathological features support the diagnosis of MB type BL leprosy even though the results of the skin slit smear examination were negative.
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Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Staphylococcus aureus
Views: 1,391Downloads: 1,020Background: Diseases due to infection where one of the causes is Staphylococcus aureus is one of the biggest problems faced today. Treatment using penicillin antibiotics tends to cause resistance and side effects, so people prefer to overcome them by means of self-medication or the use of traditional ingredients such as betel leaf. The purpose of the study was to examine the effect of green betel leaf extract (Piper betle L.) on the growth of Staphylococcus aureus on the antibacterial activity.
Methods: This study is experimental research in vitro using a well diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 5%, 10%, 15%, and 20%.
Results: The average diameter of the inhibition zones was 9.82 mm, 9.11 mm, 9.28 mm, and 9.01 mm at concentrations of 5%, 10%, 15%, and 20%, sequentially.
Conclusion: The antibacterial activity of betel leaf extract in the overall concentration and the most optimal concentration was 5% at 9.82 mm.
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Effectiveness Test of Green Betel Leaf Extract (Piper betle L.) on the Growth of Candida albicans
Views: 1,561Downloads: 955Background: Candida albicans is a fungus that often results in opportunistic infections in humans, called candidiasis. People generally practice self-medication to treat candidiasis with azole antifungals. However, this causes resistance due to inappropriate drug or dose selection. Betel leaf extract, which contains active compounds with antifungal properties such as phenols, tannins, and flavonoids, can be used as alternative medicine. The purpose of this study was to determine whether there was an effect of green betel leaf extract (Piper betle L.) on the growth of Candida albicans.
Methods: This study is an experimental study and uses the disc diffusion method. The betel leaf was extracted using the maceration method and made into concentrations of 40%, 60%, 80%, and 100%.
Results: The mean inhibition zone diameters were 9.12 mm, 8.79 mm, 8.18 mm, and 8.55 mm at concentrations of 40%, 60%, 80%, and 100%, sequentially.
Conclusion: Betel leaf extract has an antifungal effect, with the most effective concentration being 40%.
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Effect of Okra Fruit (Abelmoschus esculentus) Extract on Granzyme Expression and Tumor Mass Diameter of Adenocarcinoma Mammae: An In Vivo Study
Views: 738Downloads: 521Background: Breast cancer is currently one of the most common types of cancer suffered by women, with the highest prevalence in all countries in the world. Herbal plants are thought to increase the immune system against tumors, one of which is okra (Abelmoschus esculentus) has the potential as an anti-tumor and anti-carcinogenic. This study aimed to assess the efficacy of ethanol okra extract on granzyme expression and tumor mass diameter in mammary adenocarcinoma of rats treated with adriamycin-cyclophosphamide chemotherapy.
Methods: This study is an experimental study using 28 Sprague Dawley Rats. Data analysis was performed with SPSS version 21 to assess differences in granzyme expression and tumor size.
Results: The combination of chemotherapy and okra fruit extract (P3) showed optimal potential in increasing granzyme expression and reducing mammary tumor size.
Conclusion: The okra fruit extract has potential in the treatment of mammary carcinoma by increasing the expression of granzymes so as to reduce the size of breast carcinoma tumors in vivo.
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Psychosomatic Aspect of the COVID-19 Pandemic
Views: 875Downloads: 936A pandemic is an epidemic of an infectious disease that spreads over a wider area, multiple continents, or the entire world at the same time. Since COVID-19 was declared a pandemic on March 11th, 2020, the world has entered a global emergency phase. The COVID-19 pandemic has changed the way of life and become a stressor in this century. Various factors become stressors during a pandemic. Many people experience negative emotions, such as fear, anxiety, and depression, during the COVID-19 pandemic. When negative emotions are no longer controlled, they will have a negative effect on the autonomic nervous system and cerebral cortex, causing psychosomatic and somatic symptoms. Many studies have shown a significant relationship between perceived stress and psychosomatic complaints. Research has also shown that stress during the COVID-19 pandemic is associated with an increase in psychosomatic symptoms. In the future, negative emotions during a pandemic, if not managed properly, can lead to post-traumatic stress disorder (PTSD). Peoples who are vulnerable to mental disorders due to COVID-19 include people with chronic diseases. Stressors during a pandemic can exacerbate anxiety, depression, and chronic stress in people with chronic diseases, causing exacerbations of chronic diseases, increasing somatic symptoms, and decreasing immune responses, resulting in increased infection and mortality risk.
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Palpebral Basal Cell Carcinoma Profile at Dr. M. Djamil General Hospital Padang, Indonesia
Views: 907Downloads: 476Background: Basal cell carcinoma (BCC) or basalioma is the world's most common type of non-melanoma skin cancer. 80% of BCC occurs in the head and neck area, and 20% occurs in the palpebrals. BCC contributes to 90-95% of malignancies that occur in the palpebrals, is more common in males, and the incidence is higher in those over 60 years of age. BCC grows slowly (slow-growing) and rarely metastasizes but can cause local destruction of surrounding structures. This study aims to explore the profile of palpebral basal cell carcinoma at Dr. M. Djamil General Hospital Padang, Indonesia.
Methods: This study is a descriptive observational study. A total of 36 research subjects participated in this study. Data analysis was performed using SPSS univariately.
Results: Palpebral basal cell carcinoma most often occurs in the age group of 61-70 years. Gender predilection is more common in men than women and generally occurs unilaterally. More people work outdoors than indoors. The inferior palpebral is the predilection for most tumor sites, and tumor invasion is found in the orbital area in 30.56% of cases. Wide excision and palpebral reconstruction are the most common treatment options.
Conclusion: Basal cell carcinoma of the lids most often occurs in the age group of 61-70 years, gender of male, unilateral, more working outdoors, the most predilection in the inferior palpebral and tumor invasion is found in the orbital area in 30.56% of cases, The most common treatments are wide excision and palpebral reconstruction.
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Comparison of Subfoveal Choroidal Thickness Values with Severity of Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients
Views: 519Downloads: 373Background: Changes in choroidal thickness may be associated with increased severity of diabetic retinopathy and may occur simultaneously or even earlier than diabetic retinopathy. This study aims to compare the value of subfoveal choroidal thickness (SCT) with the severity of RD in patients with type 2 DM without RD with NPDR at Dr. M. Djamil General Hospital Padang, Indonesia.
Methods: This research is a cross-sectional analytic observational study. The study was conducted on 36 eyes obtained from 29 study subjects. Data analysis was performed with the help of SPSS to determine the ratio of SCT thickness in diabetic retinopathy patients, p<0.05.
Results: The thickest mean SCT value was found in the type 2 DM group without RD (328.78 + 14.78 mm) and the thinnest in the severe NPDR group (234,22 + 12,30 mm).
Conclusion: The more severe the severity of diabetic retinopathy, the thinner the SCT (subfoveal choroidal thickness).
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Comparison of Central Corneal Thickness and Lamina Cribrosa Thickness in Ethnic Indians and Ethnic Malays as Predictors of Glaucomatous Optic Neuropathy
Views: 596Downloads: 397Background: Glaucoma poses a public health problem because it is the second leading cause of blindness after cataracts. A thinner central corneal thickness (CCT) is also a contributor to the development of primary open-angle glaucoma (POAG). Lamina cribrosa (LC) is a structure of the optic nerve head (ONH). LC structural changes such as thinning, posterior displacement, and connective tissue deficiency are associated with the mechanism of retinal nerve fiber layer (RNFL) thickness damage, leading to glaucomatous optic neuropathy.
Methods: Cross-sectional analytic observational study. A total of 36 eyes from 36 research subjects participated in this study. Data analysis was carried out using SPSS version 25. Then, univariate and bivariate analyzes were carried out to see the difference in CCT and LC thicknesses.
Results: The average CCT in ethnic Indians is 514.33 ± 14,142 μm and in ethnic Malays, 542.06 ± 17,234 μm. In this study, there were differences in the average CCT in Indian ethnicity and Malay ethnicity, which was statistically meaningful with a p-value = 0.000.
Conclusion: There are differences in the average central corneal thickness and lamina cribrosa thickness in ethnic Indians compared to ethnic Malays, where the central corneal thickness and lamina cribrosa thickness in ethnic Indians are thinner than ethnic Malays.
