The Efficacy of Lerek Fruits (Phrynium maximum)Extract Related Body Weight, Lipid Profile and Leptin in Wistar Rats-Induced High Fat Diet

  • Radiyati Umi Partan Faculty of Medicine Universitas Sriwijaya
  • Rachmat Hidayat Faculty of Medicine Universitas Sriwijaya
  • Yeni Agustin Faculty of Medicine Universitas Sriwijaya
  • Mgs Irsan Saleh Faculty of Medicine Universitas Sriwijaya
  • Nita Parisa
  • Evi Lusiana Faculty of Medicine Universitas Sriwijaya
  • Nia savitri Tamzil Faculty of Medicine Universitas Sriwijaya
  • Ayeshah Agusta Rosdah Faculty of Medicine Universitas Sriwijaya
  • Abdulwahab Hakimi

Abstract

Background


Phrynium maximum (local name : lerek ) is a plant native to Sumatera, Malaya and Borneo. This plants have a potential as a local wisdom for therapeutics. In Sumatera, Lerek was used as traditional treatment for fever, diarrhea, diabetics and for wound healing.


 


Aim of Study


Aim of this study to explore the efficacy of lerek fruits extract in body weight, lipid profile and leptin level in Wistar Rats-Induced High Fat Diet


 


Methods


This study was an experimental study , pre-post test with control group design. The sample in this study was  30 male rats, 8 weeks old, weight 150-200 gram. Rats were given high fat diet and lerek fruits extract  at dose of 50, 100 and 200 mg/kgBW/day for 2 weeks. Lerek fruits was extracted by infusion methods. The results of this study were assayed by SPSS 18.


 


Results


Lerek fruit extract 100 mg/kgBW  was more potent to reduce body weight gain, triglyseride level and leptin level than lerek fruit extract 50 mg/kgBW, 200 mg.kgBW, negative control and positive control.


 


Conclusion


Lerek fruit extracts had a potention to reduce body weight, triglyceride and leptin level.


 


Keywords: Lerek fruit extract – body weight- triglyserida - leptin

Published
2017-10-31
How to Cite
PARTAN, Radiyati Umi et al. The Efficacy of Lerek Fruits (Phrynium maximum)Extract Related Body Weight, Lipid Profile and Leptin in Wistar Rats-Induced High Fat Diet. Bioscientia Medicina : Journal of Biomedicine and Translational Research, [S.l.], v. 1, n. 1, p. 8-13, oct. 2017. ISSN 2598-0580. Available at: <http://bioscmed.com/index.php/bsm/article/view/10>. Date accessed: 17 oct. 2019. doi: https://doi.org/10.32539/bsm.v1i1.10.

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