Accreditation
SINTA 2Nationally Accredited Journal
Vol. 2 No. 3 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Articles
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The The Effect of Active Gambir (Uncaria gambir) Fraction on TNF-α Protein Expression and Lesion Size in White Rats Gastritis Model
Views: 1,359Downloads: 435Background: Gambir (Uncaria gambir) is empirically used to treat abdominal pain and vomittus caused by gastritis because of its anti-inflammatory effects, especially flavonoid. This study aims to determine the effect of active gambir fraction on TNF-α protein expression and wound size in white rats gastritis model.
Methods: The research method used experimental study design in vivo with post test with control group design. Rats were divided randomly in 11 groups and were induced to be gastritis for 1 day. Group 1 (negative control) was given aquadest of 5 mL, group 2 (positive control) was administered ranitidine 10 mg/kgBW, groups 3, 4, and 5 were given n-hexane fraction, groups 6, 7 and 8 were given a water fraction, and groups of 9, 10, and 11 were given ethyl fractions with each group receives dose of 20, 40, and 80 mg/kgBW and all groups were treated for 3 days. Rats were dissected on 5th day for examination of gastric mucosal lesion size and performed ELISA expression of TNF-α expression of gastric mucosal tissue. The results of this study were assayed by SPSS 18.
Results: The result of the research using Kruskal-Wallis test showed that there were significant differences (p <0.05) of the lesions size between the sample groups where control positive, ethyl fraction 20, 40, 80 mg/kgBW, and water fraction 20, 40 mg/kgBB had the gastric mucosal lesion size differed significantly with the negative control group, while the TNF-α protein expression test using Kruskal-Wallis showed that there was a significant difference (p <0.05) TNF-α levels of all groups against the negative control.
Conclusion: Active gambir fraction had a potention to reduce size of mucose gaster lesion and reduce expression of TNF-α protein.
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Soil Transmitted Helminths (STH) Infection Related
Body Mass Index in Elementary School Students, Sukawinatan Landfill, Palembang City
Views: 1,420Downloads: 156ABSTRACT
Introduction
The age of Primary School Children are the group most often affected by worm infections with a prevalence of more than 60%. Worm infection can cause a decrease in health conditions, Body Mass Index (BMI), intelligence and productivity of sufferers so that economically causes a lot of losses and decreases in the quality of human resources.
Aims of Study
The purpose of this study was to determine the relationship of infection with Soil Transmitted Helminths (STH) with the Body Mass Index (BMI) in the children of Elementary School ( SDN 188), Sukawinatan Landfill, Sukarame District, Palembang City.
Methods
This research is an analytic observational study with a cross-sectional approach. The population consisted of all children of SDN 188 Sukarame Subdistrict, Palembang City, 109 people who were selected by consecutive sampling. Examination of helminthiasis infection was obtained by taking faecal samples on the subject and then examined by laboratory with Kato-Katz method and Body Mass Index (BMI) through anthropomometric measurements of height and weight. The analysis carried out was univariate descriptively and bivariately by Chi-square test.
Results
There were found 27 (24.8%) children who were positive for helminthiasis and from the results of the bivariate test there was no correlation between STH infection and BMI (p> 0.05).
Conclusion
there was no significant relationship between infection with Soil Transmitted Helminths (STH) and the Body Mass Index (BMI) of primary school age children around the Sukawinatan landfill in Palembang.
Keywords: STH Infection, Body Mass Indeks, Landfiil Area
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The Risk Factors of Anorectal Malformation Patients Mortality in Palembang
Views: 3,292Downloads: 117Anorectal malformations are serious anal and rectal disorders ranging from stenosis to anorectal agenesis. The incidence of mortality in cases of anorectal malformations is influenced by many factors, including the type of anorectal malformation, associated congenital anomalies, sepsis, and prematurity as investigated in this study. The aim of this study was to identify the risk factor of mortality on anorectal malformation patients. This study is an observational analytic study with cross sectional study design. Secondary data collection was obtained from eighty-two medical records of anorectal malformation patients in Dr. Mohammad Hoesin Hospital Palembang from January 2015 to June 2017 that meets the inclusion criteria. From eighty-two cases of anorectal malformations found nineteen cases of mortality (23.2%). There were four risk factors identified, anorectal malformation type, associated congenital anomalies, sepsis, and prematurity. Two risk factors found significantly affect the mortality on anorectal malformation patients, anorectal malformation type (p value = 0.036) and sepsis (p value = 0.049) from four risk factors studied. Type of anorectal malformation and sepsis have a significant effect on the mortality of patients with anorectal malformations, but there is no effect on the mortality of the patients with assciated congenital anomalies and prematurity.
Keywords: Anorectal malformation, congenital abnormalities, sepsis, prematurity
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The Recommended Aerobic Gymnastics Has Better Effects on Improving Cognitive and Motoric Ability in Children
Views: 2,586Downloads: 1,553Abstract
Background Cognitive and motoric ability has important role in children’s development, whereas exercise has benefit effects on those abilities. Knowledge materials mostly have dominant role in primary school curriculum. Physical exercise lesson is only complementary lesson without a target to improve children’s cognitive ability. We conducted a study to give evidence that 3x/week structured exercise program has better effect compared to 1 x/week exercise on cognitive and motoric skill ability in children. Materials and methods Children aged 6-8 years old were divided into treatment (n=34) and control group (n=33). Treatment group were performing fun aerobic gymnastics guided by trained instructor, 45 minutes each, 3 times a week for 8 weeks with intensity target. Control group were also performing the same gymnastic activity for only once a week with no target. Cognitive and motoric ability were assessed before and after intervention. Results A recommended regular exercise has better effect on executive function, reaction speed, coordination, flexibility and agility, compared to control. There were no differences on memory and balance ability. Both groups have shown better result for all indicators after exercise. Exercise in both groups has positive effect on cognitive and motoric ability, but a recommended 3 x/week regular exercise has better effects compared to 1 x/week exercise. Conclusions School program should give more portions for exercise activity in their curriculum.
Keywords: Gymnastics exercise, cognitive ability, motoric ability
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The Efficacy of Sauropus androgynus Leaves Extract To Improve Cognitive Function in Wistar Rats Induced Alzheimer’s
Views: 1,847Downloads: 192Background
Sauropus androgynus leaves is the substance which has the potency to prevent degenerative processes. Sauropus androgynus leaves has flavonoid as the main component. Flavonoid has antioxidant and anti neuro-inflammation that can be used to prevent Alzheimer dementia. Research purpose is knowing the effect of Sauropus androgynus leaves for the cognitive function and β-amyloid expression in the hippocampus of wistar rats.
Methods
Reseacrh was done by in vivo method, where male wistar rats (n=24) were distributed to six groups which consisting of four rats. Group 1: Normal control, group 2: positive control, group 3: standard treatment (B12 vitamin), group 4, 5 and 6 were give Sauropus androgynus leaves extract with the dose of 75 mg/kgBB, 150 mg/kgBB and 300 mg/kgBB, respectively for 28 days. Cognitive function was evaluated by t-maze test, where hippocampal β-amyloid expression was tested by immunohistochemistry.
Results
Time differences (day 0-28), alternation ratio distinction (day 0-28) and β-amiloid expression were: group 1 (1,84 second; 0,23 unit; 0,518%), group 2 (56,78 second; -0,42 unit; 40,036%), group 3 (34,46 second; -0,25 unit; 33,08%), group 4 (32,83 second; -0,09 unit; 28,88%), group 5 (-3,91 second; 0,42 unit; 14,728%), group 6 (24,25 second; 0,42 unit; 9,4%).
Conclusion
Sauropus androgynus leaves extract at the dose of 150 mg/kgBB and 300 mg/kgBB can maintain cognitive function by decreasing hippocampal β-amyloid formation.
