Accreditation
SINTA 2Nationally Accredited Journal
Vol. 5 No. 9 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Articles
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WHO Global Strategy in Eradication of Cervical Cancer
Views: 1,262Downloads: 648WHO has created a global strategy to accelerate the elimination of cervical cancer
as a public health problem and a world burden. Cervical cancer is a disease that
can be prevented and cured, as long as it is detected early and treated effectively.
Cervical cancer is also a disease that reflects global injustice. The burden is
greatest in low- and middle-income countries, where access to public health
services is limited and screening and treatment for the disease has not been widely
applied. In 2018, nearly 90% of all deaths worldwide occurred in low and middle
income countries. Furthermore, the proportion of women with cervical cancer who
die from the disease is more than 60% in these countries, more than double the
number in many high-income countries, which is only 30%. -
Histopathological Features of Cutaneous Tuberculoid Granuloma Disorders
Views: 2,110Downloads: 3,374Tuberculoid granulomas consist of epithelioid histiocytes, Langhans giant cells and rarely foreign bodies with lymphocytes, plasma cells and caseous necrosis. The granulomatous reaction pattern is defined as a typical inflammatory pattern that is characterized by granulomas. Various etiologies can lead to granulomatous reactions. The histopathological features of cutaneous disorders with tuberculoid granuloma include cutaneous tuberculosis, tuberculids, Morbus Hansen, syphilis and rosacea. There are various clinical manifestations of tuberculoid granuloma with similar appearances which makes it difficult to establish a definitive diagnosis. The histopathological features of cutaneous tuberculoid granuloma disorders can support the diagnosis. Therefore, the clinician can determine the appropriate treatment with the right diagnosis.
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Laparoscopic Davydov Procedure for Creation of Neovagina in MRKH Syndrome
Views: 2,439Downloads: 592Introduction: The Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a condition in which there is an absence of the uterus and the upper part (2/3) of the vagina. Women with MRKH syndrome show normal development of secondary sexual characteristics and a normal 46, XX karyotype. MRKH syndrome is a common cause of primary amenorrhea. Ultrasonography examination confirms kidneys, presence of the ovaries, and absence of uterus. Treatment should include a multidisciplinary approach to create a functional vagina. One of the procedures is laparoscopic Davydov vaginoplasty.
Aim: To report MRKH syndrome case treated with laparoscopic Davydov vaginoplasty.
Method: Ms. A, 21 years old, P0A0, came to FER clinic Moh. Hoesin Hospital Palembang with complaint, never had menstruation, the patient admitted her breast, and her pubic had growth. She wants to get married in the next six months. From the US result, there was non visualized uterus, genital band (+), and both ovaries within normal limit ~ MRKH Syndrome. Karyotype Examination: 46, XX. Patient was diagnosed with primary amenorrhea caused by MRKH syndrome and was planned for neovagina (Davydov Procedure).
Result: A woman 21-year-old, P0A0, was diagnosed with primary amenorrhea caused by MRKH syndrome. The Davydov procedure was done to create a neovagina. Intraoperative, after protrusion of the wood mold as a marker shown, an incision is made to the left and right side so that the mold penetrates the abdominal cavity, then the mold is pulled into the vaginal canal slowly. The anterior and posterior peritoneal layers are drawn into the vaginal canal. The anterior and posterior peritoneal layers were withdrawn with an ovum clamp and then interrupted suture. The anterior and posterior peritoneal layers were sutured in a circular method to form a vaginal cuff. The vaginal wall is sutured (interrupted) to hold mold fixed.
Conclusion: MRKH syndrome is a disorder that occurs in females and mainly affects the reproductive system. This condition causes the vagina and the uterus to be underdeveloped or even absent at birth. Patients with diagnosed MRKH syndrome require interdisciplinary care. Davydov procedure is a laparoscopically-assisted technique, which has an advantage over traditional approaches. It has shorter operating time, lower intraoperative complications, shorter hospital stay, and no external scars. Postoperatively, sexual function is similar to women without gynecological disorders.
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Factors Associated with The Incidence of Infection in Tracheostomy Stoma at Mohammad Hoesin Hospital
Views: 1,965Downloads: 2,035Introduction: Tracheostomy is a surgery to open the trachea to allow air to enter the airway. Tracheostomy cannot be separated from possible complications. Tracheostomy stoma infection is one of the complications of post-tracheostomy that occurs due to the activity of several bacteria. Many factros can cause the incidence of tracheostomy stoma infection.
Objective: The aim of this study is to determine the factors associated with the incidence of tracheostomy stoma infection.
Methods: Observational study with cross-sectional design. Data collection was carried out using medical record data on 71 subjects who underwent tracheostomy tube replacement from july 2019 to November 2020.
Results: From 71 subjects, it was found that the subjects who had tracheostomy stoma infection were 54.9%. The results of bivariate analysis showed that age (p=0.031), comorbidities (p=0.009), the type of tracheostomy tube (p=0.015), the use of antiseptic in tracheostomy dressing (p=0.020), tracheostomy tube care (p=0.013), and the interval of changing the tracheostomy tube (p=0.041) are the significant factors. The results of multivariate analysis showed that tracheostomy tube care and the interval of changing the tracheostomy tube had a significant effect on tracheostomy stoma infection. Tracheostomy tube care has a risk of 9.362 times to experience infection with CI95%(1.535-57.086) and the interval of changing the tracheostomy tube has a risk of 10.669 with CI95% (1.074-105.985).
Conclusion: There is a significant relationship between age, comorbidities, type of tracheostomy tube, the use of antiseptic in tracheosotmy dressing, tracheosotmy tube care, and interval of changing the tracheostomy tube with the incidence of tracheostomy stoma infection.
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Handling of Common Laboratory Animals in Biomedical Study
Views: 3,105Downloads: 1,371Mice are usually caught and lifted by the tail. The tail should be grasped about
two-thirds of the way down. With this simple method of holding, they may be
transferred to another cage or a balance, identified or sexed; but such restraint is
not sufficient for treatment and close examination. For more effective control, the
mouse may be held by the tail and placed on a table or other surface, preferably
one that the mouse can grasp, and the loose skin over the neck and shoulders
grasped with thumb and fingers. -
The Relationship between Plasma Hypocretin Levels and Sleep Disorders in Patients with Parkinson's Disease
Views: 1,098Downloads: 607Introduction: There are many areas of brain degeneration in people with Parkinson's disease. The dopaminergic degeneration process in the midbrain causes early symptoms of sleep disturbances. Hypocretin produced by the hypothalamus is involved in the pathophysiology of Parkinson's disease. Some research results regarding the relationship between plasma hypocretin levels and sleep disorders in patients with Parkinson's disease are still controversial.
Method: This research is a cross sectional study in Neurology Polyclinic Dr. M. Djamil Padang and Network Hospital. All research subjects measured hypocretin levels and sleep disorders using the Epworth Sleepiness Scale. Statistical analysis was performed on a computerized basis using IBM SPSS statistics version 23.0 for windows.
Result: A total of 60 patients with Parkinson's disease were included in this study, 30 subjects experienced sleep disorders and 30 others had no sleep disorders. There was a significant difference in lower plasma hypocretin levels in the Parkinson's group with sleep disorders, namely 81.817 ± 22.770 and in the group without sleep disorders, plasma hypocretin levels were found to be 255.416 ± 226.590 (p = 0.000). There was no statistical difference in clinical degree, age, duration of illness between the Parkinson's group with sleep disorders and the group without sleep disorders p > 0.05.
Conclusion: There is a significant difference in hypocretin levels against the sleep disorder group in people with Parkinson's disease. In this study, there was no association between age, clinical degree of Parkinson's disease, and duration of Parkinson's disease and sleep disturbances. Degeneration in the olfactory bulb area, hypothalamus, and brainstem can precede dopaminergic degeneration in the midbrain and cause sleep disturbance symptoms.
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Correlation of Serum IL-6 Levels with Muscle Mass, Muscle Strength, and Physical Performance in Elderly Gymnastics Community in Mohammad Hoesin General Hospital Palembang
Views: 1,119Downloads: 696Introduction. Old age is related to geriatric syndrome where there are several health problems that often occur related to a decrease in body function and an increase in the inflammatory process. Decrease in muscle mass, muscle strength and physical performance will cause a condition of sarcopenia and frailty syndrome in the elderly. The importance of prevention so that sarcopenia does not occur in the elderly by evaluating the factors that can cause it, one of which is controlling interleukin 6 (IL-6) as proinflammatory. The purpose of this study was to determine the correlation between serum IL-6 levels with muscle mass, muscle strength and physical performance in the elderly gymnastics-community in Mohammad Hoesin General Hospital, Palembang.
Methods. This research is an observational analytic study with a cross-sectional approach which was conducted at the Integrated Geriatric Clinic Internal Medicine RSMH Palembang from November 2019 to November 2020. A sample of 31 people aged > 60 years was examined for muscle mass, muscle strength, physical performance and IL-levels. 6 serum. All data processing and analysis in this study used the SPSS version 25 for Windows program.
Results. of the 31 subjects, 27 were female (87.1%) and 4 male (12.9%). The mean value of muscle mass is37.9 kg/m2, muscle strength 23 kg, and physical performance 6.1 m/sec.There were 28 (90.3%) samples with elevated serum IL-6 levels, while 3 (9.7%) samples had normal levels. There was a significant negative correlation (p = 0.000) with a strong correlation strength (r = -0.722) between serum IL-6 levels and muscle mass and a significant negative correlation (p = 0.050) with a weak correlation strength (r = -0.354) between IL levels -6 serums with physical performance.
Conclusions. There was a significant negative correlation between serum IL-6 levels and muscle mass and physical performance. So, it is very important to prevent an increase in serum IL-6 levels so that the elderly do not fall into a state of sarcopenia.
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Risk Factors For The Event Of Pediculosis Capitis In The Baturaja Orphanage, South Sumatera, Indonesia
Views: 1,631Downloads: 716Introduction. Pediculosis capitis is a disease of the scalp caused by infestation of Pediculus humanus capitis with symptoms such as itching and sensation of movement in the hair. The purpose of this study was to determine the risk factors and incidence of pediculosis capitis in the Baturaja orphanage.
Methods. This research is an analytic observational study using a cross-sectional design with field and laboratory research. The population of this study were all children in the Baturaja orphanage who met the inclusion and exclusion criteria, as many as 172 children. All children present were taken as subjects. Data obtained by questionnaires, interviews and direct observation of the sample.
Results. The results of this study showed the prevalence of pediculosis capitis in the Baturaja orphanage was 19.1%. In this study, it was found that there was a significant relationship between age (p = 0.000), education (p = 0.000), the use of shared pillows (p = 0.000), the use of shared combs (p = 0.000), the use of shared towels (p = 0.000), knowledge (p = 0.000), attitudes and behavior (p = 0.000) with the incidence of pediculosis capitis. Multivariate analysis showed that the most dominant risk factor for the incidence of pediculosis capitis in the Baturaja orphanage was age (p=0.036), while behavior was a protective factor for the incidence of pediculosis capitis.
Conclusion. There is a significant relationship between age, education, use of shared pillows, use of shared combs, use of shared towels, knowledge, attitudes, behavior with the incidence of pediculosis capitis. The most dominant risk factor for the incidence of pediculosis capitis in the Baturaja orphanage is age, while behavior is a protective factor for the incidence of pediculosis capitis. -
Effects of Oral Administration of Monosodium Glutamate (MSG) on Obesity in Male Wistar Rats (Rattus Norvegicus)
Views: 1,915Downloads: 1,097Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).
Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.
Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.
Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days. -
Relationship between 25-Hydroxy Vitamin D Levels and Type of Morbus Hansen
Views: 992Downloads: 684Background: Morbus Hansen is a chronic granulomatous infection of Mycobacterium leprae (M. leprae) which is characterized by cardinal signs in the form of numbness of the skin, thickening of peripheral nerves and acid-fast bacteria (AFB) were found on bacterioscopic examination. WHO has classified MH into paucibasilar MH (MH-PB) and multibasilar MH (MH-MB) based on the number of skin lesions or bacterial index (IB). Vitamin D in MH is known to act as an immunomodulator. This study aims to determine the relationship between serum 25(OH)D levels with Morbus Hansen type at RSUP Dr. Mohammad Hoesin and Leprosy Hospital Dr. Rivai Abdullah Palembang.
Methods: A laboratory observational study with a case series design was undertaken at the Dermatology and Venereology (DV) Polyclinic of Infectious Dermatology (DI) Mohammad Hoesin Hospital Palembang since December 2019 to January 2020. A sample of 33 patient MH met the inclusion criteria, consisting of 22 patients with Morbus Hansen (MH) type MB and 11 patients with Morbus Hansen (MH) type PB. Comparison of serum 25(OH)D levels between MB and PB type MH patients was analyzed using the Independent T Test, the relationship between serum 25(OH)D levels and MH type was analyzed using the Fisher Exact Test and the correlation between serum 25(OH)D levels with type of MH was analyzed using Spearman Rho's test. Data analysis using SPSS version 22.0.
Results: In this study, there were no differences in demographic characteristics of gender, age, age category, body mass index, education and occupation between MB and PB type MH patients (p > 0.05). There were no difference in duration of therapy (p = 0.155), ENL reaction (p = 0.276) and patient status (p = 0.304) between MB and PB type MH patients, but there were differences in bacterial index (p = 0.000) and clinical spectrum (p = 0.000) between MB and PB type MH patients. There is a difference in the mean level of 25(OH)D between MB and PB type MH patients (p = 0.006), there is a significant relationship between 25 (OH)D levels and MH type patients, (OR = 9.643 ; p = 0.010) and there is a significant moderate positive correlation between levels of 25 (OH)D and the type of MH (r = 0.467; p = 0.006).
Conclusion: It can be concluded that there are differences in serum 25(OH)D levels among Morbus Hansen type. In addition, there is a significant relationship between serum 25(OH)D levels with Morbus Hansen type.
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Recurrence Prediction Score of the Localy Advance Breast Cancer in West Sumatera Province, Indonesia
Views: 777Downloads: 501Introduction: Breast cancer is the most common malignancy that occurs in women in the world, which is about 18% of cancer cases that occur in women. Every year there are 1 million new cases of breast cancer worldwide and nearly 60,000 patients die from this disease. Therefore, the authors want to find out more about the prognosis factors that play a role in influencing the survival of patients with locally advanced breast cancer in Padang city, West Sumatera Province Indonesia.
Methods: This study is a retrospective case-control study of locally advanced breast cancer for patients in Padang city. The study was conducted at the Surgical Oncology Division of Dr. M Djamil Padang Hospital, Ropana Suri Hospital, Ibnu Sina Hospital and Siti Rahmah Padang Hospital from September 2018 to December 2018. The total number of samples for the two groups was 242 people. The sampling technique used was convenience sampling.
Results: In this study 4 prognostic factors were found that had a significant effect on predicting breast cancer recurrence, namely histopathological type, stage, regional lymph and lymphovascular invasion with p <0.05.
Conclusion: Prognosis factors that influence breast cancer recurrence are histopathological type, stage, regional lymph node status and lymphovascular invasion. A scoring system is obtained that is good enough to predict the possibility of breast cancer recurrence.
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Primary Squamous Cell Carcinoma Thyroid with Regional Recurrence
Views: 749Downloads: 569Background. Primary squamous cell carcinoma (PSCC) of the thyroid is a very aggressive malignancy with a poor prognosis. There is no consensus for the management of primary squamous cell carcinoma (PSCC) of the thyroid, and this is based on rare cases in which the frequency of occurrence is less than 1% of thyroid malignancies. How squamous cell carcinoma originates in the thyroid gland is an interesting topic to discuss, because the thyroid gland does not have a squamous cell epithelium.
Case Presentation. A 43-year-old man was admitted to the DR Kariadi Hospital with complaints of a lump on the right neck. In June 2020, the patient complained of a lump in the right neck area with a diameter of about 1x1x1 cm, no pain. Ultrasound of the colli at the regional hospital showed the impression of multiple lymphadenopathy of the right colli level 2-5, and there were cystic nodules with solid parts in the right and left lobes of the thyroid suspected of being benign. An adenectomy operation was performed at a regional hospital and the impression of metastatic squamous undifferentiated carcinoma was obtained.
Conclusion. The management of thyroid PSCC is a multimodality therapy, namely surgery, chemotherapy and radiation.
