Accreditation
SINTA 2Nationally Accredited Journal
Vol. 7 No. 5 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Articles
-
Factors Affecting the Outcome of Breast Reconstruction Surgery in Modified Radical Mastectomy Procedure
Views: 648Downloads: 351Background: Breast cancer is the leading cause of death in women caused by cancer. The primary treatment for breast cancer is surgery, where several recommended surgical methods are breast-conserving surgery or mastectomy. Postoperative mastectomy reconstruction has provided an opportunity to overcome the emotional and aesthetic burden of malignancy.
Methods: This research is a descriptive observational study with a retrospective approach. The sample was 45 breast cancer patients who had undergone a modified radical mastectomy operation at Dr. Kariadi General Hospital for January 2019 - April 2023. The data were processed using SPSS for Windows software, and a descriptive analysis was carried out.
Results: Most of the patients who underwent post-MRM breast reconstruction were in the age group >40 years (71.1%), had stage 2 mammary carcinoma (44.4%) and stage 3 (40%), featured invasive ductal carcinoma (84 .4%), breast on the right side (64.4%). Some suffer from hypertension (13.3%) or diabetes mellitus (22.2%). The most used type of reconstruction was STSG (82.2%). A small proportion of patients experienced dehiscence (17.8%). In the Karnofsky score assessment, the highest score was 70 (64.4%), followed by 60 (17.8%), 80 (11.1%), 50 (4.4%), and 40 (2.2%).
Conclusion: The patients undergoing MRM are dominated by the age group > 40 years, not suffering from hypertension or diabetes mellitus, stage 2, histopathology of invasive ductal carcinoma, right-sided breast. STSG dominates the choice of reconstruction with postoperative complications in the form of dehiscence in a small proportion of patients. The Karnofsky score is dominated by a score of 70.
-
Atlas of Human Oocyte: A Review in the Daily In Vitro Fertilization (IVF) Practices
Views: 760Downloads: 1,366Background: Oocytes are gamete cells that play an important role in the daily practice of in vitro fertilization (IVF) laboratories. Oocyte morphology is important to study and assess in order to increase the success of IVF pregnancy.
Methods: A computerized database search process in Pub med was performed to obtain data. Then, the most updated and relevant articles were selected.
Results: Normal oocyte morphology should have normal-appearing cytoplasm, single polar body, appropriate zona pellucida (ZP) thickness, and appropriate perivitelline space (PVS). Abnormal oocyte morphology can be in the form of immature oocytes, large in size, ovoid or amorphous in shape, having fragment/double/multiple polar body I (PBI) and granular cytoplasm or smooth endoplasmic reticulum (SER).
Conclusion: Abnormal oocyte morphology in the IVF laboratory can be seen by its maturity level, size, shape, condition of PBI, and cytoplasmic granularity. A better selection of oocytes can increase the performance of the IVF laboratory.
-
Bilateral Technique of Penis Flap with Scrotum Skin in Penile Paraffinoma Cases: A Case Report
Views: 844Downloads: 756Background: Paraffin injection into the penis is one way that people see it as increasing penis size. But many do not know that paraffin injection actually causes side effects in the form of penile paraffinoma. This study aimed to describe the management of paraffinoma using bilateral techniques.
Case presentation: A 40-year-old married man came to the emergency room at Samuel J. Moeda Naval Hospital, Kupang, with complaints of pain and swelling of the penis for 6 hours. The pain felt to get worse when the penis was erected. The genital organs found swelling of the entire penile skin accompanied by tenderness and induration. The bilateral scrotal flap technique was because the scrotal skin had many blood vessels, good flexibility, little adipose tissue, thin skin, and could feel erogenous sensations almost the same as the physiological characteristics of the penile skin.
Conclusion: Bilateral scrotal flap technique on the penile shaft is a surgical technique that is quite effective in eradicating paraffin from penile tissue.
-
Biological Reconstruction for Metacarpal Osteofibrous Dysplasia Treatment: A Case Report
Views: 536Downloads: 398Background: Osteofibrous dysplasia is a rare benign bone tumor characterized by abnormal differentiation of fibrous tissue in bone and commonly involves the maxilla, mandible, and tibia and affects children less than 10 years old. Osteofibrous dysplasia affecting the metacarpal is a very rare case. This study presents a case report to present biological reconstruction in the management of metacarpal osteofibrous dysplasia.
Case presentation: A 48-year-old female presented with swelling and pain in her right hand over 1 year. On examination, palpable mass with immobile and hard consistency on the first metacarpal and distal neurovascular within normal limit. Radiographic examination (X-ray and MRI) supports osteofibrous dysplasia. We performed complete resection of the first metacarpal and used a fibular graft to maintain length, followed by arthroplasty of the first metacarpophalangeal joint and arthrodesis of the first carpometacarpal joint. Pathological results showed a Chinese letter appearance with osteoblastic rimming that confirmed osteofibrous dysplasia. After 6 months of follow-up, there is no recurrence, and the functional outcome is excellent (MSTS score 93,33%).
Conclusion: Osteofibrous dysplasia on the metacarpal and affected adult is a very rare case. Treatment with complete resection of the metacarpal, using a fibular graft to maintain bone length, and arthroplasty MCP joint will give good results (MSTS score 93,33%). Follow-up for recurrence is necessary.
-
Intensive Management of Diffuse Peritonitis Caused by Spontaneously Healed Gastric Perforation: A Case Report
Views: 1,853Downloads: 629Background: Gastric perforation will cause acute peritonitis. Proper diagnosis and management, especially in ICU, are needed to prevent complications and even death from this event. This study aimed to describe the intensive management of diffuse peritonitis caused by gastric perforation.
Case presentation: A 61 years old male patient presented with pain in the whole abdomen for 6 days before admission. The pain began at the epigastrium and suddenly spread to the whole abdomen. The pain was felt continuously and increased by movement. Routine blood examination revealed anemia, lekousitosis, and radiology examination found homogeneous confluence was found in the abdominal, dilated small intestine, psoas line was not visible, in the left lateral decubitus position, an air-fluid level and free air were found. The patient underwent diagnostic laparoscopic surgery + peritoneal lavage on emergency surgery for 2 hours, obtained a resolution of gastric perforation, and the patient was treated postoperatively in the ICU of Dr. M. Djamil General Hospital.
Conclusion: Cases of spontaneous resolution of gastric perforation are not only in terms of surgical management but in terms of postoperative care. It also plays an important role in the success and good results in cases of gastric perforation.
-
Analysis of Factors Associated with Adherence to Taking Medication in Pediatric Patients with Pulmonary Tuberculosis in Mesuji Regency, Lampung, Indonesia
Views: 699Downloads: 539Background: One disease that is still a health problem in the world, including Indonesia, is tuberculosis (TB) which is caused by germs Mycobacterium tuberculosis. The success of TB treatment requires patient compliance in taking antituberculosis drugs (OAT), family support such as supervision, and motivating TB sufferers are factors that play a role in patient compliance. This study aims to determine the factors associated with medication adherence in pediatric patients with pulmonary tuberculosis in Mesuji Regency, Lampung, Indonesia.
Methods: This study was an observational study with a cross-sectional approach, where as many as 52 respondents were included in this study. Data collection through interviews using a structured questionnaire. The subject of the study consisted of tuberculosis patients who were reported to have attended treatment for at least two months in Mesuji Regency. Data analysis was carried out using SPSS using univariate and bivariate methods.
Results: The results showed that 76.9% of respondents adhered to the treatment of pulmonary tuberculosis. Patient medication adherence to tuberculosis was influenced by the presence of drug side effects (p-value = 0.007) and the supervisor's support for taking medication (p-value = 0.021).
Conclusion: Compliance with taking medication in tuberculosis patients is influenced by the presence of medication supervisors and the uncomfortable side effects of antituberculosis drugs.
-
The Relationship of Gastrointestinal Disorders to Malnutrition in Children with Cerebral Palsy in the WKCP Community (Wahana Keluarga Cerebral Palsy) Yogyakarta, Indonesia
Views: 777Downloads: 582Background: One of the causes of malnutrition that often occurs is gastrointestinal disorders. The existence of anatomical and physiological abnormalities in the gastrointestinal tract is the main cause. This study aimed to assess the relationship between gastrointestinal disorders and the incidence of malnutrition in children with cerebral palsy in the WKCP community Yogyakarta, Indonesia.
Methods: A cross-sectional analytic observational study involving 20 cerebral palsy subjects who met the inclusion and exclusion criteria. The data collection technique is by consecutive sampling. The type of data used in the research uses a questionnaire gastrointestinal symptoms rating scale (GSRS). Data status anthropometry has also been collected. Data analysis using SPSS with chi-square.
Results: The mean age of the subjects was 8.9 ± 4.1 years. The male gender (60%) is greater than the female. The comparison of good nutritional status and malnutrition is not much different, namely 55%:45%, respectively. The percentage of children experiencing severe gastrointestinal symptoms is 25%. The most common gastrointestinal disorders are constipation (65%) and upper dysmotility disorders (60%). In the results of this study, there was no relationship between gastrointestinal disorders and the incidence of malnutrition (p=0.069).
Conclusion: In this study, there was no significant relationship between gastrointestinal disorders and malnutrition in children with cerebral palsy. However, gastrointestinal disorders increase the morbidity and mortality of children with cerebral palsy, so it must be an important concern.
-
The Relationship between Basic Sanitation of Healthy Homes and Personal Household Hygiene with the Incidence of Stunting in Toddlers in Residential Area around TPA Cipeucang in 2023
Views: 701Downloads: 466Background: Stunting is one of the problems of malnutrition in toddlers in Indonesia. Environmental sanitation has an important role in stunting. Waste management that has not been maximized at the TPA can cause environmental sanitation pollution and a lack of clean living behavior. Cipeucang TPA is the only TPA for the South Tangerang area, with 2 Sub-Districts that are close to the TPA experiencing an increase in stunting cases in 2021-2022. This study aimed to determine the relationship between basic sanitation in a healthy home and personal hygiene households with the incidence of stunting in toddlers in the residential area around TPA Cipeucang.
Methods: This type of research is observational analytic through a cross-sectional approach. The study population was all toddlers in settlements around the TPA covering 2 Sub-Districts with 4 RT and 2 RW. The research sample was 86 using a purposive sampling technique. The research was conducted from April to June 2023. Data analysis used univariate, bivariate (Chi-square test), and multivariate (logistic regression test).
Results: The results showed that there was a relationship between drinking water facilities and stunting (p=0.05, POR=1.89), and became the dominant factor causing stunting (p=0.054). While clean water facilities (p=0.374, POR=1.44), latrines (p=0.613, POR=1.22), wastewater disposal facilities (p=1.000, POR=1.54), skin hygiene (p =1.000, POR=1.24) and hand and nail hygiene (p=0.625, POR=1.22) were not related to stunting but were risk factors for stunting. Waste management facilities (p=0.310) have no relationship with stunting and are not a risk factor.
Conclusion: There is a relationship between drinking water facilities and the incidence of stunting in toddlers in the residential area around TPA Cipeucang.
-
Ecological Study of Climate Effects on Malaria Incidence in Jayapura Indonesia 2010-2022
Views: 738Downloads: 638Background: Malaria is still a health problem in Indonesia with high geography, rainfall and humidity. Malaria infects people living in endemic areas, especially in tropical and subtropical countries. Malaria can be a public health threat in remote areas. Jayapura is one of the cities in Indonesia with a high incidence of malaria. This event is supported by the geographical position and dominant topography in the form of swamp areas, sago forests, forests, mountains, and environmental influences such as temperature, rainfall, and air humidity. This study aimed to determine the effect of climatic factors consisting of monthly cumulative rainfall, average air temperature monthly average and monthly average relative humidity on the number of monthly malaria cases in Jayapura.
Methods: This study uses observation by using ecological-based studies and ecological time-trend design.
Results: This study found that rainfall and the incidence of malaria in the city of Jayapura in 2010-2022 had a significant relationship and had a positive relationship at lag 2 in 2010. Air temperature and malaria in the city of Jayapura in 2010-2022 had a significant relationship and had a positive lag 2 in 2010 and 2011. The relative humidity and incidence of malaria in Jayapura in 2010-2022 had a significant relationship and had a negative relationship at a 2-month lag in 2011 and 2015 while in 2013 and 2014 it had a strong and positive relationship.
Conclusion: Ecological studies found a significant relationship between climate and malaria incidence in Jayapura.
