Acute Changes in Cartilage Oligomeric Matrix Protein and CTX-II Following Endurance Running in Adults: A Systematic Review and Meta-analysis
DOI:
https://doi.org/10.37275/bsm.v10i10.1668Keywords:
Cartilage oligomeric matrix protein, CTX-II, Endurance running, Cartilage biomarkers, Meta-analysisAbstract
Background: Acute running-related changes in cartilage oligomeric matrix protein (COMP) and the C-terminal cross-linked telopeptide of type II collagen (CTX-II) should not be interpreted automatically as structural cartilage injury. This review evaluated the magnitude and consistency of these biomarker responses after endurance running.
Objective: To quantify the magnitude and consistency of the immediate post-run change in serum cartilage oligomeric matrix protein (COMP), and to summarize the corresponding CTX-II responses, in adults following endurance running.
Methods: The protocol was registered in PROSPERO (CRD420261485170). PubMed/MEDLINE, CENTRAL, ClinicalTrials.gov, WHO ICTRP, OpenAlex, Crossref, and citation networks were searched for adult running studies reporting pre- and post-exercise COMP or CTX-II. The primary effect was the log ratio of immediate post-run to pre-run serum COMP. Random-effects models used restricted maximum likelihood with Hartung-Knapp inference.
Results: The search identified 221 unique reports; seven reports met the criteria for qualitative synthesis, and four compatible healthy-adult COMP estimates involving 57 participants entered the meta-analysis. The pooled post/pre ratio was 1.132 (95% CI 0.794–1.613), with τ²=0.0365, I²=89.0%, and a 95% prediction interval of 0.560–2.286 at ρ=0.50. Three estimates increased and one decreased after running. CTX-II and recovery findings were too heterogeneous for pooling. Certainty was very low.
Conclusion: Serum COMP may change acutely after endurance running, but the direction and magnitude are inconsistent. These short-term surrogate responses do not establish cartilage damage, protection, or long-term clinical harm.
Authors
- Made Anggi Paramitha1*
- Bagus Gede Krisna Astayogi1
- Komang Adinda Permitasari Bramastya1
- 1Faculty of Medicine, Universitas Mahasaraswati, Denpasar, Indonesia
Corresponding author Made Anggi Paramitha — madeanggi940@gmail.com
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Copyright (c) 2026 Made Anggi Paramitha, Bagus Gede Krisna Astayogi, Komang Adinda Permitasari Bramastya
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