Accreditation
SINTA 2Nationally Accredited Journal
Vol. 3 No. 1 (2019): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Articles
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Association of Stress Level with Menstrual Disturbance Among Female Students in Medical Faculty Sriwijaya University
Views: 2,750Downloads: 1,978Association Of Stress Level With Menstrual Cycle Disturbance Among Female Students In Medical Faculty Of Sriwijaya University. Menstruation occurs regularly every month will form a menstrual cycle. Normal menstrual cycles in women range from 21-35 days. However, the menstrual cycle is not always normal, many women experience menstrual disturbance. Menstrual cycle disturbance are caused by several factors, which is stress. This study aims to analyze the association of stress level with menstrual cycle disturbance among female students in Medical Faculty of Sriwijaya University. This study is analytical cross-sectional study with primary data from menstrual cycle, stress ISMA, personality type DSM V questionnaires.. In this study, 503 samples are fulfilled inclusion criteria. Among 503 subjects, 59 (11.7%) female students experienced polymenorrhea, 391 (77.7%) female students had normal menstrual cycles, 53 (10.6%) female students experienced olygomenorrhea. Chi Square test showed that there was an association between stress level and menstrual cycle disturbance. There is a significant association between between stress level and menstrual cycle disturbance among female students in Medical Faculty of Sriwijaya University.
Keywords: Stress level, Menstrual cycle disturbance.
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The Relationships between Neutrophil/Lymphocyte Ratio and Child-Turcotte-Pugh Classification in Assessing Severity of Liver Cirrhosis
Views: 2,840Downloads: 918Background
Liver cirrhosis is a disease with high morbidity and mortality in Indonesia. The Child-Turcotte-Pugh classification is a noninvasive parameter to assess severity of liver cirrhosis. Meanwhile, the neutrophil/lymphocyte ratio can reflect person's immunity to liver cirrhosis. This study was conducted to determine the agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in assessing severity of liver cirrhosis.
Methods
Analytical observational study with Cohen’s Kappa agreement test was conducted in 86 liver cirrhosis patients. Data was retrieved by observing the medical records. Neutrophil count, lymphocyte count, hepatic encephalopathy, ascites, albumin, bilirubin, and INR were all recorded. Documented variables were analyzed by the Cohen’s Kappa agreement test.
Results
In Cohen’s Kappa agreement test, there was moderate agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in all samples (κ = 0.591 and p <0.001). Agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification based on age and gender was found to be κ = 0.777 at age ≤45 years, κ = 0.532 at age >45 years, κ = 0.682 in male, and κ = 0.445 in female (p <0.001). The highest agreement is the substantial agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification obtained at age ≤45 years (κ = 0.777 and p <0.001) and male (κ = 0.682 and p <0.001).
Conclusion
There is moderate agreement between neutrophil/lymphocyte ratio and Child-Turcotte-Pugh classification in assessing severity of liver cirrhosis. Substantial agreement obtained at age ≤45 years and male gender.
Keywords: Neutrophil/Lymphocyte Ratio, Child-Turcotte-Pugh, Liver Cirrhosis
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The Effect of Ischemic-Reperfusion on Acute Kidney Injury Pathogenesis to the Glomerular Microscopic Appearance and Cystatin C Level in Wistar White Rat.
Views: 2,394Downloads: 905Acute kidney injury (AKI) is a sudden decrease of kidney function. The incidence of AKI is increasing every year. One of the causes of AKI is the lack of blood supply to the kidneys (prerenal). At the present time, there are not many studies that report unilateral ischemic-reperfusion (UIR) duration which can cause kidney damage especially glomerulus. The aim of this study is to determine the effect of UIR duration to glomerular microscopic appearance, GFR and cystatin C produced in Wistar white rats. This study was performed in vivo by using Post-test Only Control Group Design. Unilateral Ischemic-Reperfusion was administered on the rat’s left kidney and recovery was done according to specified time. After recovery time, rat’s blood was taken, the rat was euthanized, and its kidneys were taken and stained with Picrosirius Red coloring. The kidneys were observed by using OptiLED and the photos were analyzed with ImageJ software. Blood samples were tested by ELISA to measure the cystatin C levels and the levels were converted into Larrson formula to obtain Glomerular Filtration Rate. The level of cystatin C increased along with the longer duration of UIR and compared inversely proportional to GFR which decreased along with the rise of UIR duration. Cystatin C and GFR had a significant mean difference (p<0.05) with all groups, except for the duration of the UIR group <60 minutes. The percentage of collagen obtained fluctuated but the whole group which was carried out by UIR had a significantly different collagen amount (p <0.05) with the sham-operated group. The average glomerular picture showed the addition of collagen, Bowman's capsule thickening and vascular retraction. The longer duration of UIR will worsen the kidney function.
Keywords: Unilateral Ischemic-Reperfusion, Cystatin C. Glomerular Filtration Rate, Collagen Area Fraction, Glomerulus
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Sleep and Bone Density: A Study on Postmenopausal Indonesian Women
Views: 1,246Downloads: 964Background: Low bone density has been known as one of the factors that increased fracture risk. Aging, estrogen deficiency, low BMI, and inadequate calcium intake are known factors that contribute to decreased bone density. Other than the known factors, some research show that sleep duration can also lower bone density. Sleep affects bone density in a way that it causes increased level of cortisol, proinflammatory cytokine, and decreased in physical activity.
Method: This study is an observational analytic study with cross-sectional design. It is conducted on menopausal patients that has been examined with bone mineral densitometry at Poliklinik Reumatologi Penyakit Dalam RSUP Dr. Mohammad Hoesin Palembang in November 2017 to Oktober 2018. Samples are collected using total sampling technique.
Results: From 93 subjects that participated in this study, 20,4% of them had osteopenia, and 51,6% had osteoporosis. Patients with low bone density, mainly slept for 6 to 8 hours at night per day, 30 minutes of nap per day, and has a total sleep duration for less than 8 hours each day. This study shows no significant association between night-time sleep, daytime napping, and total sleep duration with bone density (p value = 0,168, p value = 0,831, p value = 0,984). Analysis on other risk factors show significant association between body mass index and low bone density (p value = 0,002).
Conclusion: There are no significant association between sleep duration and bone density in menopausal patients at Poliklinik Reumatologi RSUP Dr. Mohammad Hoesin Palembang.
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Association of Sociodemographic, Knowledge, Attitude and Practice with Pediculosis Capitis
Views: 2,072Downloads: 1,271Introduction : Pediculosis capitis is an infection of scalp and hair in humans caused by infestation of Pediculus humanus capitis and usually extends rapidly in a dense environment such as boarding schools. Aim of study : The aim of this study was to determine the association of students’ sociodemographic, knowledge, attitude and practice with pediculosis capitis in Pondok Pesantren Tahfidzil Qur'an Yayasan Tijarotal Lan Tabur Palembang.
Methods : This research was an analytical observational study with a cross sectional design conducted on November 2018. There were 117 samples that had the inclusion criteria and hadn’t exclusion criteria. Data collected from anamnesis, questionnaires and hair examinations of respondents. The results were analyzed using Chi-Square and Logistic Regression.
Results : Out of 117 students, 57 students (48.7%) has been found positive pediculosis capitis. Statistical test showed that age (p<0.001), gender (p<0.001), education level (p<0.001), knowledge (p=0.035), attitude (p=0.003) and practice (p =0.043) have significant association to the prevalence of pediculosis capitis. However, there was no significant association between father's education (p=1.000), mother's education (p=0.743), father's job (p=0.314), mother's job (p=1.000) and parents' income (p=1.000) to the prevalence of pediculosis capitis. The results of Multiple Logistic Regression analysis showed that gender, knowledge and practice were the most influential factors to the prevalence of pediculosis capitis (p<0.05) with the probability of 96.7%.
Conclusion : There was a significant association between age, gender, education level, knowledge, attitude and practice to the prevalence of pediculosis capitis, and the most dominant variables were gender, knowledge and practice.
