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A B S T R A C T
Phyllanthus niruri (local name : meniran) extract is utilized in treating
kidney and uterus disease. Effects of ethanol extract of P. niruri on kidney
and uterus of 2% NaCl triggered fibrotic rats had been studied. Aim of
Study Aim of this study to explore the effect of leafflower (Phyllanthus
niruri Linn.) treatment on kidney and uterus in 2% NaCl - induced
fibrotic rats. Methods Wistar rats were challenged with 2% NaCl in
drinking water to induce fibrotic kidney and uterus. Phyllanthus niruri
extract (200 mg/kg) was given orally for 4 weeks. Matrix extracellular
abundance was determined by HE Staining and measured by METAVIR
Fibrosis Score. The results of this study were assayed by SPSS 16.
Results P. niruri extract was potent to reduce the matrix extracellular in
2% NaCl-induced rats compared to control group (p<0.05).
Conclusion P. niruri extract was potent to decrease the matrix
extracellular in the kidney and uterus of the rats.