Efficacy of Exosome Adipose-Derived Stem Cells (ACSs-Exosome) on Skin Flaps Transplantation in Plastic Surgery: A Systematic Literature Review
DOI:
https://doi.org/10.37275/bsm.v6i11.614Keywords:
Adipose-derived stem cells, Exosomes, Flap transplantation, Plastic surgeryAbstract
Background: Exosomes are a small subset of extracellular vesicles with a size of about 50 nm – 200 nm, which are found in many body fluids. The exosome is rich in various proteins and is a cargo that carries out the process of transporting and transporting between cells in the context of cell communication. This becomes a potential new therapeutic modality in triggering the modulation and activity of target cells so that ACSs-Exosome becomes a new potential to modulate skin flap transplantation repair in plastic surgery.
Methods: The literature search process was carried out in various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the use of ASCs-exosome in skin flap transplantation repair in plastic surgery cases.
Results: A total of 5 studies were included in this systematic review. In general, ASCs-exosome administration was more effective in the percentage of flap survival area than in the placebo group. There are 3 studies that state that the effectiveness of flap area survival is more than 70 percent compared to the placebo group, which is only in the range of 30-40 percent.
Conclusion: ASCs-exosome has the potential to be developed to improve the survival rate of skin flap transplantation in the case of plastic surgery.
Authors
- Rachmat Hidayat1*
- Patricia Wulandari2
- 1Department of Biology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
- 2Cattleya Mental Health Center, Palembang, Indonesia
Corresponding author Rachmat Hidayat — dr.rachmat.hidayat@gmail.com
Article history
- Submitted
- Accepted
- Published
Downloads
Published
Issue
Section
License
Copyright and licensing
Copyright in each article remains with the author(s). Authors grant Bioscientia Medicina: Journal of Biomedicine and Translational Research a non-exclusive right of first publication and the right to identify itself as the original publisher. No exclusive transfer of copyright is required.
All articles are published under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0): https://creativecommons.org/licenses/by-nc-sa/4.0/. Users may copy, redistribute, remix, transform, and build upon the material for non-commercial purposes, provided appropriate attribution is given, a link to the license is supplied, changes are indicated, and adaptations are distributed under the same license.
The license applies to the article's scholarly content unless a credit line states otherwise. Third-party material may be subject to separate rights. Authors retain patent, trademark, moral, and research-data rights. The copyright year follows the article's publication date.
