Efficacy of Exosome Adipose-Derived Stem Cells (ACSs-Exosome) on Skin Flaps Transplantation in Plastic Surgery: A Systematic Literature Review
DOI:
https://doi.org/10.37275/bsm.v6i11.614Keywords:
Adipose-derived stem cells, Exosomes, Flap transplantation, Plastic surgeryAbstract
Background: Exosomes are a small subset of extracellular vesicles with a size of about 50 nm – 200 nm, which are found in many body fluids. The exosome is rich in various proteins and is a cargo that carries out the process of transporting and transporting between cells in the context of cell communication. This becomes a potential new therapeutic modality in triggering the modulation and activity of target cells so that ACSs-Exosome becomes a new potential to modulate skin flap transplantation repair in plastic surgery.
Methods: The literature search process was carried out in various databases (PubMed, Web of Sciences, EMBASE, Cochrane Libraries, and Google Scholar) regarding the use of ASCs-exosome in skin flap transplantation repair in plastic surgery cases.
Results: A total of 5 studies were included in this systematic review. In general, ASCs-exosome administration was more effective in the percentage of flap survival area than in the placebo group. There are 3 studies that state that the effectiveness of flap area survival is more than 70 percent compared to the placebo group, which is only in the range of 30-40 percent.
Conclusion: ASCs-exosome has the potential to be developed to improve the survival rate of skin flap transplantation in the case of plastic surgery.
Authors
- Rachmat Hidayat1*
- Patricia Wulandari2
- 1Department of Biology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
- 2Cattleya Mental Health Center, Palembang, Indonesia
Corresponding author Rachmat Hidayat — dr.rachmat.hidayat@gmail.com
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