Correlation of Interleukin-6 Levels with Clinical Features and Chest X-Ray Imaging in Coronavirus Disease-19 (COVID-19) Patients at Dr. Mohammad Hoesin General Hospital Palembang
DOI:
https://doi.org/10.37275/bsm.v6i5.515Keywords:
COVID-19, Interleukin-6, Chest X-ray, Clinical featuresAbstract
Background. COVID-19 infection, both moderate and severe symptoms can cause pneumonia that can be detected on a chest X-ray. Along with the increasing severity of the clinical picture of COVID 19, it can also trigger a cytokine storm, one of which is an increase in Interleukin-6 levels. This study was conducted to see the correlation between IL-6 levels with clinical features and chest radiographs in patients with COVID-19
Methods. This research is a cross-sectional study using an observational analytic. The samples in this study were confirmed COVID-19 patients who were being treated at Dr. Mohammad Hoesin General Hospital, Palembang. A history and physical examination were performed to determine the clinical picture as well as a chest X-ray and IL-6 levels.
Results. There were 31 samples of COVID 19 patients. High levels of IL-6 were found in 26 (83.9%) samples. The clinical picture of the patient was dominated by dyspnea as much as 19 (61.3%), fever 16 (5.6%), low O2 saturation 12 (38.4%) and a chest X-ray of pneumonia 26 (83.9%). There was a significant relationship (P<0.05) between IL-6 levels with clinical features and chest X-rays. The R-value on the thorax with pneumonia (0.692), lesion area (0.711) and clinical features with temperature (0.906), respiratory rate (0.706) indicated a strong correlation, while O2 (-0.732) indicated a strong negative correlation.
Conclusion. There is a significantly strong correlation between Interleukin 6 levels with clinical features and chest X-rays in patients with COVID-19.
Authors
- Raden Yudistira Dwi Ananda1*
- Nova Kurniati2
- Harun Hudari3
- Erial Bahar4
- 1Specialized Recidency Training, Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya/ Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
- 2Allergy Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya/ Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
- 3Tropical Infection Division, Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya/ Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia
- 4Department of Anatomy, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Corresponding author Raden Yudistira Dwi Ananda — yudadokter2404@gmail.com
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