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Abstract
Granuloma ingunale (GI) or donovanosis is a genital ulcer disease caused by the
Calymmatobacterium granulomatis. It is a Gram-negative, facultative, obligate
intracellular and pleomorphic bacterium. This bacterium has phylogenetically
closed to and placed within the Klebsiella genus. Clinically, the disease is com-
monly characterized as painless, slowly progressive ulcerative lesions on the
genitals or perineum without regional lymphadenopathy. The lesions are highly
vascular and bleed easily on contact Extragenital lesions may occur but are rare
and more common in newborns from mothers with GI genital lesions. This
disease is often neglected, therefore it is often misdiagnosed and inaccurate
therapy. Treatment time is 3 weeks or until clinical cure has been achieved for
all proposed regimens. It often occurs both in men and women of reproductive
age (20-40 years). This article consists of several theoretical references that have
been viewed to have a better understanding of GI.
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